Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person PIAS4 SUMOylates MDC1

Class:Id	Reaction:5684052
_displayName	PIAS4 SUMOylates MDC1
_doRelease	TRUE
_timestamp	2022-01-21 20:30:11
authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5684057] SUMO transferase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5684067] Orlic-Milacic, Marija, 2015-03-18
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input	[Complex:5683808] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] [Homo sapiens] [Complex:2993778] SUMO2:UBE2I [nucleoplasm] [Homo sapiens] [Complex:2993778] SUMO2:UBE2I [nucleoplasm] [Homo sapiens] [Complex:2993778] SUMO2:UBE2I [nucleoplasm] [Homo sapiens] [Complex:2993778] SUMO2:UBE2I [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:4570503] Sumoylation of MDC1 is important for proper DNA damage response [LiteratureReference:5655625] SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage
modified	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 [InstanceEdit:5693272] Orlic-Milacic, Marija, 2015-05-14 [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:6784817] Orlic-Milacic, Marija, 2015-06-22 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792497] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9762397] May, Bruce, 2022-01-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PIAS4 SUMOylates MDC1
output	[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [Complex:5684053] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5683801] CHEK2 phosphorylates BRCA1 [Homo sapiens] [Reaction:5683792] p-T68-CHEK2 autophosphorylates [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796702] R-HSA-5684052.3
summation	[Summation:5684060] PIAS4 SUMOylates MDC1 at lysine residue K1840. The exact tim...
(hasEvent)	[Pathway:5693607] Processing of DNA double-strand break ends [Homo sapiens]
(precedingEvent)	[Reaction:5684071] RNF4 ubiquitinates MDC1 [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by PIAS4 SUMOylates MDC1 (5684052)