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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person Diagram of Nonhomologous End-Joining (NHEJ)

Class:IdPathwayDiagram:5683853
_displayNameDiagram of Nonhomologous End-Joining (NHEJ)
_timestamp2022-01-25 15:46:19
created[InstanceEdit:5683854] Orlic-Milacic, Marija, 2015-03-17
height1097
modified[InstanceEdit:5683856] Orlic-Milacic, Marija, 2015-03-17
[InstanceEdit:5686694] Orlic-Milacic, Marija, 2015-04-02
[InstanceEdit:5686700] Orlic-Milacic, Marija, 2015-04-02
[InstanceEdit:5686739] Orlic-Milacic, Marija, 2015-04-02
[InstanceEdit:5686903] Orlic-Milacic, Marija, 2015-04-05
[InstanceEdit:5686927] Orlic-Milacic, Marija, 2015-04-06
[InstanceEdit:5687157] Orlic-Milacic, Marija, 2015-04-06
[InstanceEdit:5687202] Orlic-Milacic, Marija, 2015-04-06
[InstanceEdit:5687226] Orlic-Milacic, Marija, 2015-04-06
[InstanceEdit:5687248] Orlic-Milacic, Marija, 2015-04-07
[InstanceEdit:5687249] Orlic-Milacic, Marija, 2015-04-07
[InstanceEdit:5687250] Orlic-Milacic, Marija, 2015-04-07
[InstanceEdit:5687254] Orlic-Milacic, Marija, 2015-04-07
[InstanceEdit:5687347] Orlic-Milacic, Marija, 2015-04-07
[InstanceEdit:5687357] Orlic-Milacic, Marija, 2015-04-07
[InstanceEdit:5687359] Orlic-Milacic, Marija, 2015-04-07
[InstanceEdit:5687423] Orlic-Milacic, Marija, 2015-04-07
[InstanceEdit:5687450] Orlic-Milacic, Marija, 2015-04-07
[InstanceEdit:5687455] Orlic-Milacic, Marija, 2015-04-07
[InstanceEdit:5693457] Orlic-Milacic, Marija, 2015-05-15
[InstanceEdit:5693458] Orlic-Milacic, Marija, 2015-05-15
[InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16
[InstanceEdit:5694672] Orlic-Milacic, Marija, 2015-05-22
[InstanceEdit:5694673] Orlic-Milacic, Marija, 2015-05-22
[InstanceEdit:6790453] Orlic-Milacic, Marija, 2015-08-10
[InstanceEdit:6792497] Orlic-Milacic, Marija, 2015-08-24
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:9707305] Orlic-Milacic, Marija, 2020-11-12
[InstanceEdit:9762402] Orlic-Milacic, Marija, 2022-01-24
[InstanceEdit:9762492] Orlic-Milacic, Marija, 2022-01-25
[InstanceEdit:9762493] Orlic-Milacic, Marija, 2022-01-25
representedPathway[Pathway:5693571] Nonhomologous End-Joining (NHEJ) [Homo sapiens]
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reactionType="Association"> <Inputs> <Input id="98" points="1176 273" /> <Input id="292" points="1286 253" /> </Inputs> <Outputs> <Output id="293" /> </Outputs> <Properties> <displayName>TP53BP1 recruits DCLRE1C to ATM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="308" reactomeId="5686704" points="1619 340, 1618 370, 1622 395" position="1618 370" lineWidth="1.0"> <Inputs> <Input id="309" points="1595 336" /> <Input id="293" points="1619 305" /> </Inputs> <Outputs> <Output id="98" points="1176 305" /> <Output id="310" points="1625 580" /> <Output id="311" points="1651 393" /> </Outputs> <Catalysts> <Catalyst id="293" points="1636 305, 1657 358" /> </Catalysts> <Properties> <displayName>Activated ATM phosphorylates DCLRE1C</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="453" reactomeId="5686924" points="1556 812, 1556 813, 1556 866" position="1556 813" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="585" points="1489 780" /> <Input id="310" points="1622 608" /> </Inputs> <Outputs> <Output id="454" /> </Outputs> <Properties> <displayName>DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="879" reactomeId="5687183" points="1378 877, 1338 877, 1299 878" position="1338 877" lineWidth="1.0"> <Inputs> <Input id="880" points="1385 918" /> <Input id="454" points="1405 878" /> </Inputs> <Outputs> <Output id="881" points="1236 892" /> <Output id="882" points="1287 921" /> </Outputs> <Catalysts> <Catalyst id="454" points="1470 866, 1368 845" /> </Catalysts> <Properties> <displayName>PRKDC phosphorylates DCLRE1C at DNA DSBs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2795" reactomeId="5687360" points="779 600, 778 572, 776 550" position="778 572" lineWidth="1.0"> <Inputs> <Input id="2796" points="747 601" /> <Input id="3526" points="776 620" /> </Inputs> <Outputs> <Output id="2797" points="733 550" /> <Output id="2798" points="777 531" /> </Outputs> <Catalysts> <Catalyst id="3526" points="797 620, 817 601" /> </Catalysts> <Properties> <displayName>POLL or POLM extends aligned DNA DSB ends to fill gaps</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3455" reactomeId="5693599" points="1061 368, 1087 376, 1225 399" position="1087 376" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="98" points="1033 322" /> <Input id="208" stoichiometry="2" points="934 359" /> </Inputs> <Outputs> <Output id="213" points="1354 567" /> <Output id="220" points="1371 422" /> <Output id="212" points="1087 502" /> <Output id="217" points="1453 554" /> <Output id="382" points="704 311, 702 429" /> <Output id="216" points="1431 504" /> <Output id="219" points="1248 556" /> <Output id="209" points="1317 392" /> <Output id="90" points="762 349, 758 410" /> <Output id="3527" points="1347 651" /> <Output id="3552" points="1084 552" /> <Output id="215" points="1024 437" /> <Output id="210" points="1015 509" /> <Output id="6" points="1184 606" /> <Output id="218" points="1444 600" /> </Outputs> <Properties> <displayName>Association of Ku heterodimer with ends of DNA double-strand break</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3471" reactomeId="5693615" points="1183 691, 1185 691, 1175 736" position="1185 691" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="8" stoichiometry="2" points="1122 683" /> <Input id="6" points="1182 642" /> </Inputs> <Outputs> <Output id="9" /> </Outputs> <Properties> <displayName>Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3472" reactomeId="5693575" points="1267 760, 1290 760, 1317 759" position="1290 760" lineWidth="1.0"> <Inputs> <Input id="3524" points="1257 797" /> <Input id="9" points="1246 759" /> </Inputs> <Outputs> <Output id="585" points="1342 757" /> <Output id="3525" points="1321 795" /> </Outputs> <Catalysts> <Catalyst id="9" points="1236 736, 1271 728" /> </Catalysts> <Properties> <displayName>DNA-PKcs autophosphorylates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3505" reactomeId="5693533" points="979 926, 934 929, 878 931" position="934 929" lineWidth="1.0"> <Inputs> <Input id="881" /> </Inputs> <Outputs> <Output id="3528" /> </Outputs> <Catalysts> <Catalyst id="881" points="979 904, 945 900" /> </Catalysts> <Properties> <displayName>DCLRE1C (ARTEMIS) processes DNA DSB ends</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3506" reactomeId="5693578" points="759 910, 760 870, 759 832" position="760 870" lineWidth="1.0"> <Inputs> <Input id="3528" /> </Inputs> <Outputs> <Output id="2375" /> </Outputs> <Catalysts> <Catalyst id="29" points="707 872" /> </Catalysts> <Properties> <displayName>TDP1 and TDP2 process unligatable DSB ends</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3507" reactomeId="5693574" points="764 733, 765 733, 771 679" position="765 733" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1320" points="567 729" /> <Input id="2684" points="587 680" /> <Input id="44" points="526 776" /> <Input id="2375" points="760 773" /> </Inputs> <Outputs> <Output id="3526" /> </Outputs> <Properties> <displayName>XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3523" reactomeId="5693604" points="619 508, 557 511, 461 500" position="557 511" lineWidth="1.0"> <Inputs> <Input id="2798" /> </Inputs> <Outputs> <Output id="1305" points="258 636" /> <Output id="1304" stoichiometry="2" points="266 529" /> <Output id="1320" points="527 714" /> <Output id="2684" points="545 650" /> <Output id="44" points="481 768" /> <Output id="208" stoichiometry="2" points="843 370" /> <Output id="3454" points="361 472" /> </Outputs> <Catalysts> <Catalyst id="2798" points="619 485, 579 481" /> </Catalysts> <Properties> <displayName>XRCC4:LIG4 ligates DNA DSB ends during NHEJ</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="3549" interactionType="Activate" points="232 195, 233 270" position="232 232" lineWidth="2.0"> <Inputs> <Input id="3529" /> </Inputs> <Outputs> <Output id="3530" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="3550" interactionType="Activate" points="335 163, 401 163" position="368 163" lineWidth="2.0"> <Inputs> <Input id="3529" /> </Inputs> <Outputs> <Output id="91" /> </Outputs> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Nonhomologous End-Joining (NHEJ) (5683853)
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