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Details on Person CHEK2 is recruited to DNA DSBs

Class:IdReaction:5683735
_displayNameCHEK2 is recruited to DNA DSBs
_doReleaseTRUE
_timestamp2022-02-22 12:56:34
authored[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:5683734] Orlic-Milacic, Marija, 2015-03-16
edited[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input[Complex:5683605] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:113824] CHEK2 [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:110405] 53BP1, a mediator of the DNA damage checkpoint.
[LiteratureReference:5683732] NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway
modified[InstanceEdit:5687761] Orlic-Milacic, Marija, 2015-04-08
[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
[InstanceEdit:5693232] Orlic-Milacic, Marija, 2015-05-14
[InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16
[InstanceEdit:6784750] Orlic-Milacic, Marija, 2015-06-22
[InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24
[InstanceEdit:6792497] Orlic-Milacic, Marija, 2015-08-24
[InstanceEdit:9766481] Orlic-Milacic, Marija, 2022-02-22
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameCHEK2 is recruited to DNA DSBs
negativePrecedingEvent[NegativePrecedingEvent:9766480] Futile Cycle: Phosphorylation and activation of CHEK2 by ATM
output[Complex:5683737] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2015-09-22
releaseStatusNEW
reviewed[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6796690] R-HSA-5683735.3
summation[Summation:5683736] CHEK2 (CHK2, Cds1) is recruited to DNA double-strand breaks ...
(hasEvent)[Pathway:69473] G2/M DNA damage checkpoint [Homo sapiens]
[Pathway:5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks [Homo sapiens]
(precedingEvent)[Reaction:69891] Phosphorylation and activation of CHEK2 by ATM [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775634] Update Tracker - [Reaction:5683735] CHEK2 is recruited to DNA DSBs - v78:[modifyText]
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No pathways have been reviewed or authored by CHEK2 is recruited to DNA DSBs (5683735)
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