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Details on Person Formation of BRCA1-A complex at DNA DSBs

Class:Id	Reaction:5683385
_displayName	Formation of BRCA1-A complex at DNA DSBs
_doRelease	TRUE
_timestamp	2020-11-10 11:58:57
authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5683383] Orlic-Milacic, Marija, 2015-03-13
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input	[Complex:5683388] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:UIMC1:p-S406-FAM175A [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5682579] BRE [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5682577] BRCC3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5682582] BABAM1 [nucleoplasm] [Homo sapiens] [DefinedSet:9707070] BRCA1:BARD1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5683382] Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response [LiteratureReference:5683611] NBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes [LiteratureReference:5683618] Role of MERIT40 in stabilization of BRCA1 complex: a protein-protein interaction study [LiteratureReference:5683623] NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control
modified	[InstanceEdit:5683608] Orlic-Milacic, Marija, 2015-03-16 [InstanceEdit:5683620] Orlic-Milacic, Marija, 2015-03-16 [InstanceEdit:5683627] Orlic-Milacic, Marija, 2015-03-16 [InstanceEdit:5687761] Orlic-Milacic, Marija, 2015-04-08 [InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 [InstanceEdit:5693250] Orlic-Milacic, Marija, 2015-05-14 [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792497] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9701013] Orlic-Milacic, Marija, 2020-09-23 [InstanceEdit:9707072] Orlic-Milacic, Marija, 2020-11-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Formation of BRCA1-A complex at DNA DSBs
output	[Complex:5683387] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5683384] UIMC1 and FAM175A bind DNA DSBs [Homo sapiens] [Reaction:5683425] ATM phosphorylates TP53BP1 at DNA DSBs [Homo sapiens] [Reaction:5659781] BRCA1 forms a heterodimer with BARD1 [Homo sapiens] [Reaction:9701000] BRCA1:BARD1 heterodimer autoubiquitinates [Homo sapiens] [Reaction:5659781] BRCA1 forms a heterodimer with BARD1 [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796686] R-HSA-5683385.3
summation	[Summation:5683602] A DNA damage-independent phosphorylation of FAM175A (Abraxas...
(hasEvent)	[Pathway:5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks [Homo sapiens]
(precedingEvent)	[Reaction:5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM [Homo sapiens]
(replacementInstances)	[_Deleted:6793046] Deletion of instance: 83570
(updatedInstance)	[_UpdateTracker:9775670] Update Tracker - [Reaction:5683385] Formation of BRCA1-A complex at DNA DSBs - v78:[modifyText] [_UpdateTracker:9776526] Update Tracker - [Reaction:5683385] Formation of BRCA1-A complex at DNA DSBs - v75:[add_removeInput]
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