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Details on Person AMBRA1 (activating molecule in Beclin 1-related autophagy 1)...

Class:IdSummation:5683341
_displayNameAMBRA1 (activating molecule in Beclin 1-related autophagy 1)...
_timestamp2015-03-17 16:15:41
created[InstanceEdit:5683339] Jupe, Steve, 2015-03-13
literatureReference[LiteratureReference:5671605] Ambra1 regulates autophagy and development of the nervous system
[LiteratureReference:1632851] The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy
[LiteratureReference:5683336] Unleashing the Ambra1-Beclin 1 complex from dynein chains: Ulk1 sets Ambra1 free to induce autophagy
[LiteratureReference:5683334] Ambra1 is an essential regulator of autophagy and apoptosis in SW620 cells: pro-survival role of Ambra1
modified[InstanceEdit:5683921] Jupe, Steve, 2015-03-17
textAMBRA1 (activating molecule in Beclin 1-related autophagy 1) is a mammalian scaffold protein that interacts with BECN1 (Beclin-1) in the Beclin-1 complex, which consists of BECN1, PIK3C3 (VPS34), PIK3R4 (VPS15) and ATG14. AMBRA1 promotes the interaction of BECN1 with PIK3C3 (Fimia et al. 2007). AMBRA1 can simultaneously bind dynein and the Beclin-1 complex. This anchors Beclin-1 complexes to the cytoplasmic microtubule network (Di Bartolomeo et al. 2010, Fimia et al. 2011). Downregulation of AMBRA1 increased staurosporine- or etoposide-induced apoptosis (Gu et al. 2014).
(summation)[Reaction:5678313] AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex [Homo sapiens]
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