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Details on Person Variant ABCB1 does not transport xenobiotics from cytosol to extracellular region
| Class:Id | FailedReaction:5683197 |
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| _displayName | Variant ABCB1 does not transport xenobiotics from cytosol to extracellular region |
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| _timestamp | 2016-07-15 23:49:04 |
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| authored | [InstanceEdit:5683200] Jassal, Bijay, 2015-03-12 |
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| catalystActivity | [CatalystActivity:9631753] ABC-type xenobiotic transporter activity of ABCB1 S893A [plasma membrane] |
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| compartment | [Compartment:876] plasma membrane
[Compartment:70101] cytosol |
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| created | [InstanceEdit:5683200] Jassal, Bijay, 2015-03-12 |
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| disease | [Disease:5683147] inflammatory bowel disease |
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| edited | [InstanceEdit:5683200] Jassal, Bijay, 2015-03-12 |
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| entityFunctionalStatus | [EntityFunctionalStatus:5683134] partial_loss_of_function of ABCB1 S893A [plasma membrane] |
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| input | [SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:1131652] a xenobiotic [cytosol] |
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| isChimeric | FALSE |
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| literatureReference | [LiteratureReference:5683171] MDR1 Ala893 polymorphism is associated with inflammatory bowel disease |
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| modified | [InstanceEdit:5684033] Jassal, Bijay, 2015-03-18
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9631717] Wu, G, 2018-12-12 |
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| name | Variant ABCB1 does not transport xenobiotics from cytosol to extracellular region |
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| normalReaction |
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| species | [Species:48887] Homo sapiens |
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| stableIdentifier | [StableIdentifier:8884886] R-HSA-5683197.1 |
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| summation | [Summation:5683199] The multidrug resistance protein 1 (ABCB1 aka MDR1, P-glycop... |
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| (hasEvent) | [Pathway:5683159] Variant ABCB1 increases susceptibility to inflammatory bowel disease 13 [Homo sapiens] |
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No pathways have been reviewed or authored by Variant ABCB1 does not transport xenobiotics from cytosol to extracellular region (5683197)
