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Details on Person UniProt:P31269 HOXA9
| Class:Id | ReferenceGeneProduct:56830 |
|---|---|
| _chainChangeLog | chain:1-272 added on Fri February 6 2015 |
| _displayName | UniProt:P31269 HOXA9 |
| _timestamp | 2026-02-20 22:44:19 |
| chain | chain:1-272 |
| checksum | 823A1A22BB07A881 |
| comment | FUNCTION Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of SELE/E-selectin and VCAM1 on the endothelial cells surface at sites of inflammation (PubMed:22269951). Positively regulates EIF4E-mediated mRNA nuclear export and also increases the translation efficiency of ODC mRNA in the cytoplasm by competing with factors which repress EIF4E activity such as PRH (By similarity).SUBUNIT Transiently interacts with PRMT5 in TNF stimulated endothelial cells (PubMed:22269951). Interacts with EIF4E (By similarity).INTERACTION Methylated on Arg-140 by PRMT5; methylation is critical for E-selectin induction.DISEASE A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98 (PubMed:8563753). The chimera includes NUP98 intrinsic disordered regions which contribute to aberrant liquid-liquid phase separation puncta of the chimera in the nucleus. This phase-separation enhances the chimera genomic targeting and induces organization of aberrant three-dimensional chromatin structures leading to tumourous transformation (PubMed:34163069).DISEASE A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2.SIMILARITY Belongs to the Abd-B homeobox family. |
| description | recommendedName: Homeobox protein Hox-A9 alternativeName: Homeobox protein Hox-1G |
| geneName | HOXA9 HOX1G |
| identifier | P31269 |
| isSequenceChanged | FALSE |
| keyword | Chromosomal rearrangement Cytoplasm Developmental protein DNA-binding Homeobox Methylation Nucleus Proteomics identification Proto-oncogene Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | HOXA9 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997747] ENSEMBL:ENSG00000078399 HOXA9 [Homo sapiens] |
| secondaryIdentifier | HXA9_HUMAN O43369 O43429 Q99820 |
| sequenceLength | 272 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:9819147] HOXA9 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P31269 HOXA9 (56830)
