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Details on Person Leucine-rich glioma inactivated 4 (LGI4) protein is another ...

Class:IdSummation:5682795
_displayNameLeucine-rich glioma inactivated 4 (LGI4) protein is another ...
_timestamp2015-04-20 10:14:41
created[InstanceEdit:5682765] Garapati, Phani Vijay, 2015-03-10
literatureReference[LiteratureReference:5682830] LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11
[LiteratureReference:5682701] Adam22 is a major neuronal receptor for Lgi4-mediated Schwann cell signaling
[LiteratureReference:5682729] The claw paw mutation reveals a role for Lgi4 in peripheral nerve development
[LiteratureReference:5688723] Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system
modified[InstanceEdit:5686054] Garapati, Phani Vijay, 2015-03-31
[InstanceEdit:5688749] Garapati, Phani Vijay, 2015-04-20
textLeucine-rich glioma inactivated 4 (LGI4) protein is another candidate ligand for ADAM22 receptor. Schwann cells secrete LGI4, which through binding to the axonal receptor ADAM22 drives axonal ensheathment and myelination in the peripheral nervous system (PNS) but not central nervous system. LGI4 secretion defect results in inability of Schwann cells to correctly myelinate peripheral nerves, resulting in peripheral nervous system hypomyelination and the murine claw-paw phenotype (Birmingham et al. 2006). LGI4 interacts with not only ADAM22 but also interacts moderately with ADAM11 and ADAM23 (Ozkaynak et al. 2010, Sagane et al. 2008, Nishino et al. 2010).
(summation)[Reaction:5682709] LGI4 binds ADAM22,23,11 [Homo sapiens]
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