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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Leucine-rich glioma inactivated 2 (LGI2) like LIG1, is neuro...

Class:IdSummation:5682740
_displayNameLeucine-rich glioma inactivated 2 (LGI2) like LIG1, is neuro...
_timestamp2015-03-31 16:01:34
created[InstanceEdit:5682765] Garapati, Phani Vijay, 2015-03-10
literatureReference[LiteratureReference:5682791] LGI2 truncation causes a remitting focal epilepsy in dogs
modified[InstanceEdit:5686054] Garapati, Phani Vijay, 2015-03-31
textLeucine-rich glioma inactivated 2 (LGI2) like LIG1, is neuronally secreted and acts on ADAM (a-disintegrin-and-metalloproteinase) family of neuronal membrane proteins, which function in synapse remodelling. Based on the experiments performed in canine and rat brain it proves that LGI2 interacts with ADAM22 and ADAM23 following secretion. Truncation of Lgi2 prevents its secretion and ADAM interactions causing remitting focal-onset epilepsy in dogs between ages one and four months, which is equivalent to human two to eight years. It has been suggested that LGI2 participates in protecting the brain against seizures during the pruning phase of neurodevelopment (Seppala et al. 2011).
(summation)[Reaction:5682769] LGI2 binds ADAM22,23 [Homo sapiens]
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