Reactome: A Curated Pathway Database
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Details on Person Atg5 interacts with the small coiled?coil protein Atg16L1. ...

Class:IdSummation:5682643
_displayNameAtg5 interacts with the small coiled?coil protein Atg16L1. ...
_timestamp2015-03-10 10:20:06
created[InstanceEdit:5682672] Jupe, Steve, 2015-03-10
literatureReference[LiteratureReference:5681990] Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway
[LiteratureReference:5681986] Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast
[LiteratureReference:5682646] Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
textAtg5 interacts with the small coiled?coil protein Atg16L1. The resulting Atg12-Atg5-Atg16L1 complex multimerizes through the oligomerization of Atg16l1 (Mizushima et al. 1999, 2003). The molecular weight of this multimeric complex suggests that it probably represents a tetramer of Atg12-Atg5-Atg16l1 (Kuma et al. 2002).
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