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Details on Person RNF8 binds phosphorylated MDC1 at DNA DSBs

Class:Id	Reaction:5682588
_displayName	RNF8 binds phosphorylated MDC1 at DNA DSBs
_doRelease	TRUE
_timestamp	2015-09-04 20:31:59
authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5682593] Orlic-Milacic, Marija, 2015-03-09
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input	[Complex:5682540] RNF8:Zn2+ [nucleoplasm] [Homo sapiens] [Complex:5682993] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5682555] Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase [LiteratureReference:5682622] Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation
modified	[InstanceEdit:5683001] Orlic-Milacic, Marija, 2015-03-11 [InstanceEdit:5687902] Orlic-Milacic, Marija, 2015-04-10 [InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 [InstanceEdit:5693279] Orlic-Milacic, Marija, 2015-05-14 [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:6784750] Orlic-Milacic, Marija, 2015-06-22 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792497] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RNF8 binds phosphorylated MDC1 at DNA DSBs
output	[Complex:5682585] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5682992] KDM4A,B bind H4K20Me2 [Homo sapiens] [Reaction:5682965] WHSC1 dimethylates histone H4 on lysine K21 at DSBs [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796674] R-HSA-5682588.2
summation	[Summation:5682592] RNF8 is an E3 ubiquitin ligase that, through its FHA domain,...
(hasEvent)	[Pathway:5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks [Homo sapiens]
(precedingEvent)	[Reaction:5682586] HERC2 and PIAS4 are recruited to DNA DSBs [Homo sapiens]
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