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Details on Person KAT5 acetylates ATM at DNA DSBs

Class:Id	Reaction:5682044
_displayName	KAT5 acetylates ATM at DNA DSBs
_doRelease	TRUE
_timestamp	2015-09-04 20:31:55
authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5682030] acetyltransferase activity of DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5682036] Orlic-Milacic, Marija, 2015-03-05
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input	[Complex:3785779] DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] [Homo sapiens] [SimpleEntity:113560] Ac-CoA [nucleoplasm] [SimpleEntity:113560] Ac-CoA [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:5682041] A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM [LiteratureReference:5682032] DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity [LiteratureReference:5682049] Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60 [LiteratureReference:5682136] HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response
modified	[InstanceEdit:5682057] Orlic-Milacic, Marija, 2015-03-05 [InstanceEdit:5682138] Orlic-Milacic, Marija, 2015-03-05 [InstanceEdit:5687761] Orlic-Milacic, Marija, 2015-04-08 [InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 [InstanceEdit:5693262] Orlic-Milacic, Marija, 2015-05-14 [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:6783379] Orlic-Milacic, Marija, 2015-06-12 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792497] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	KAT5 acetylates ATM at DNA DSBs
output	[SimpleEntity:2485002] CoA-SH [nucleoplasm] [SimpleEntity:2485002] CoA-SH [nucleoplasm] [Complex:5682035] DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5693612] MRN complex bound to DNA ends recruits ATM [Homo sapiens] [Reaction:3785768] MRN complex binds DNA double strand breaks [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796672] R-HSA-5682044.2
summation	[Summation:5682118] The histone acetyltransferase Tip60 (KAT5), in addition to f...
(hasEvent)	[Pathway:2559586] DNA Damage/Telomere Stress Induced Senescence [Homo sapiens] [Pathway:5693548] Sensing of DNA Double Strand Breaks [Homo sapiens]
(precedingEvent)	[Reaction:5693540] MRN activates ATM [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775840] Update Tracker - [Reaction:5682044] KAT5 acetylates ATM at DNA DSBs - v78:[modifyText]
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