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Details on Person MRN complex binds shortened telomeres

Class:Id	Reaction:5682020
_displayName	MRN complex binds shortened telomeres
_doRelease	TRUE
_timestamp	2015-05-25 03:49:10
authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5682019] Orlic-Milacic, Marija, 2015-03-04
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
input	[Complex:75164] MRN [nucleoplasm] [Homo sapiens] [OtherEntity:3785706] Shortened telomere [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:3785736] MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MRN complex binds shortened telomeres
output	[Complex:5682022] Shortened telomere:MRN [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:3785711] Telomere shortening during replicative exhaustion [Homo sapiens] [Reaction:181450] Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure [Homo sapiens] [BlackBoxEvent:176700] Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure [Homo sapiens]
releaseDate	2013-09-18
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695788] R-HSA-5682020.2
summation	[Summation:5682017] The MRN complex (MRE11:RAD50:NBS1 also known as MRE11A:RAD50...
(hasEvent)	[Pathway:2559586] DNA Damage/Telomere Stress Induced Senescence [Homo sapiens] [Pathway:9672999] ALT via HRR [Homo sapiens]
(precedingEvent)	[Reaction:5682018] MRN complex bound to shortened telomeres recruits ATM [Homo sapiens]
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No pathways have been reviewed or authored by MRN complex binds shortened telomeres (5682020)