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Details on Person ATG5:ATG12 binds ATG16L1

Class:Id	Reaction:5682012
_displayName	ATG5:ATG12 binds ATG16L1
_doRelease	TRUE
_timestamp	2025-02-02 00:40:52
authored	[InstanceEdit:5671581] Jupe, Steve, 2015-02-02
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5681983] Jupe, Steve, 2015-03-04
edited	[InstanceEdit:5692984] Jupe, Steve, 2015-05-13
input	[EntityWithAccessionedSequence:5671734] ATG16L1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5671734] ATG16L1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5671734] ATG16L1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5671734] ATG16L1 [cytosol] [Homo sapiens] [Complex:5683581] GlyK130-ATG5:ATG12 [cytosol] [Homo sapiens] [Complex:5683581] GlyK130-ATG5:ATG12 [cytosol] [Homo sapiens] [Complex:5683581] GlyK130-ATG5:ATG12 [cytosol] [Homo sapiens] [Complex:5683581] GlyK130-ATG5:ATG12 [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9937327] Shamovsky, Veronica, 2025-01-30
isChimeric	FALSE
literatureReference	[LiteratureReference:9936648] ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12-ATG5-ATG16L1 complex assembly and autophagy [LiteratureReference:9937328] Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners [LiteratureReference:9937330] Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy
modified	[InstanceEdit:5682015] Jupe, Steve, 2015-03-04 [InstanceEdit:5682672] Jupe, Steve, 2015-03-10 [InstanceEdit:5683589] Jupe, Steve, 2015-03-16 [InstanceEdit:5683719] Jupe, Steve, 2015-03-16 [InstanceEdit:5692976] Jupe, Steve, 2015-05-13 [InstanceEdit:5693009] Jupe, Steve, 2015-05-13 [InstanceEdit:6793655] Jupe, Steve, 2015-09-03 [InstanceEdit:9612935] Varusai, Thawfeek, 2018-07-05 [InstanceEdit:9638325] Varusai, Thawfeek, 2019-03-05 [InstanceEdit:9681506] Varusai, Thawfeek, 2020-04-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9936627] Orlic-Milacic, Marija, 2025-01-24 [InstanceEdit:9936652] Orlic-Milacic, Marija, 2025-01-25 [InstanceEdit:9937333] Orlic-Milacic, Marija, 2025-01-30 [InstanceEdit:9937335] Orlic-Milacic, Marija, 2025-01-30 [InstanceEdit:9937565] Orlic-Milacic, Marija, 2025-02-02
name	ATG5:ATG12 binds ATG16L1
output	[Complex:5679262] ATG16L1 complex [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5682690] ATG10 dissociates from ATG12:ATG5 [Homo sapiens] [Reaction:5683588] ATG10 transfers ATG12 from ATG10 to ATG5 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[NegativeRegulation:9936623] Negative regulation by 'ATG16L2 [cytosol]'
releaseDate	2015-06-17
reviewed	[InstanceEdit:5693008] Tooze, Sharon A, 2015-05-13 [InstanceEdit:6793656] Klionsky, Daniel J, 2015-09-03 [InstanceEdit:9937563] Khor, Bernard, 2025-02-01
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9638297] Varusai, Thawfeek, 2019-03-05 [InstanceEdit:9936737] Orlic-Milacic, Marija, 2025-01-25
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695786] R-HSA-5682012.7
structureModified	[InstanceEdit:9936627] Orlic-Milacic, Marija, 2025-01-24
summation	[Summation:5682000] ATG5 interacts with the small coiled-coil protein ATG16L1...
(hasEvent)	[Pathway:1632852] Macroautophagy [Homo sapiens]
(precedingEvent)	[Reaction:5679255] WIPI2 binds ATG12:ATG5:ATG16L [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9939626] Update Tracker - [Reaction:5682012] ATG5:ATG12 binds ATG16L1 - v92:[modifyText, removeLiteratureReference, removeRegulator]
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No pathways have been reviewed or authored by ATG5:ATG12 binds ATG16L1 (5682012)