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Details on Person LC3 family proteins are processed by members of the ATG4 fam...

Class:IdSummation:5682001
_displayNameLC3 family proteins are processed by members of the ATG4 fam...
_timestamp2015-03-17 16:16:19
created[InstanceEdit:5681983] Jupe, Steve, 2015-03-04
literatureReference[LiteratureReference:5671850] The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway
[LiteratureReference:5679283] HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates
[LiteratureReference:5682400] LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation
[LiteratureReference:5671826] Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates
modified[InstanceEdit:5682015] Jupe, Steve, 2015-03-04
[InstanceEdit:5682408] Jupe, Steve, 2015-03-06
[InstanceEdit:5682672] Jupe, Steve, 2015-03-10
[InstanceEdit:5683589] Jupe, Steve, 2015-03-16
[InstanceEdit:5683921] Jupe, Steve, 2015-03-17
textLC3 family proteins are processed by members of the ATG4 family, which remove a C-terminal residue to create an exposed C-terminal glycine (Kirisako et al. 2000, Tanida et al. 2004, Kabeya et al. 2004, Li et al. 2011). Processed LC3 proteins are sometimes referred to as LC3-I.
(summation)[Reaction:5681987] LC3 is cleaved by ATG4 [Homo sapiens]
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