Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of leucine biosynthesis

Class:IdPathwayDiagram:5679628
_displayNameDiagram of leucine biosynthesis
_timestamp2018-04-06 21:39:23
created[InstanceEdit:5679633] Amarasinghe, Vindhya, 2015-03-04
height1238
modified[InstanceEdit:9605079] D'Eustachio, Peter, 2018-04-06
representedPathway[Pathway:5267639] leucine biosynthesis [Arabidopsis thaliana]
storedATXML<?xml version="1.0" encoding="UTF-8"?> <Process nextId="45" reactomeDiagramId="5679628"> <Properties> <displayName>Diagram of leucine biosynthesis</displayName> </Properties> <Nodes> <org.gk.render.RenderableChemical id="11" reactomeId="5278291" position="399 97" bounds="377 82 44 30" textPosition="382 86" /> <org.gk.render.RenderableChemical id="12" reactomeId="1131337" position="386 137" bounds="355 122 62 30" textPosition="360 126"> <Properties> <displayName>Ac-CoA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="13" reactomeId="5279680" position="308 77" bounds="257 55 102 44" textPosition="264 59"> <Properties> <displayName>3-methyl-2-oxobutanoate</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="14" reactomeId="1132304" position="377 191" bounds="359 176 37 30" textPosition="364 180"> <Properties> <displayName>H+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="15" reactomeId="5279367" position="308 271" bounds="251 249 114 44" textPosition="258 253"> <Properties> <displayName>(2S)-2-isopropylmalate</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="16" reactomeId="1131323" position="380 232" bounds="348 217 64 30" textPosition="353 221"> <Properties> <displayName>CoA-SH</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="17" reactomeId="5276478" position="145 165" bounds="82 147 126 36" textPosition="85 147"> <Properties> <displayName>2-isopropylmalate synthase</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="18" reactomeId="1131563" position="308 1131" bounds="271 1116 74 30" textPosition="277 1120"> <Properties> <displayName>L-leucine</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="20" reactomeId="5278291" position="374 373" bounds="352 358 44 30" textPosition="357 362"> <Properties> <displayName>H2O</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="21" reactomeId="5279670" position="308 418" bounds="240 403 137 30" textPosition="247 407"> <Properties> <displayName>2-isopropylmaleate</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="24" reactomeId="5278291" position="369 453" bounds="347 438 44 30" textPosition="352 442" /> <org.gk.render.RenderableChemical id="25" reactomeId="5279671" position="308 583" bounds="251 561 114 44" textPosition="258 565"> <Properties> <displayName>(2R,3S)-3-isopropylmalate</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="27" reactomeId="1132064" position="369 621" bounds="342 606 54 30" textPosition="347 610"> <Properties> <displayName>NAD+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="28" reactomeId="5279669" position="308 753" bounds="245 731 127 44" textPosition="245 735"> <Properties> <displayName>(2S)-2-isopropyl-3-oxosuccinate</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="29" reactomeId="1130844" position="379 717" bounds="352 702 54 30" textPosition="357 706"> <Properties> <displayName>NADH</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="30" reactomeId="5276666" position="139 661" bounds="76 643 126 36" textPosition="79 643"> <Properties> <displayName>3-isopropylmalate dehydrogenase</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="32" reactomeId="1131665" position="308 941" bounds="234 918 148 46" textPosition="250 930"> <Properties> <displayName>2-ketoisocaproate</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="33" reactomeId="1132345" position="368 896" bounds="347 881 42 30" textPosition="351 885"> <Properties> <displayName>CO2</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="35" reactomeId="1131365" position="367 979" bounds="341 964 52 30" textPosition="347 968"> <Properties> <displayName>L-Glu</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="36" reactomeId="5278317" position="364 1094" bounds="342 1079 44 30" textPosition="347 1083"> <Properties> <displayName>2OG</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="37" reactomeId="5276667" position="144 1028" bounds="87 1003 114 50" textPosition="90 1003"> <Properties> <displayName>branched-chain-amino-acid transaminase</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="38" reactomeId="1132304" position="370 790" bounds="352 775 37 30" textPosition="357 779" /> <org.gk.render.RenderableChemical id="40" reactomeId="1132304" position="370 678" bounds="352 663 37 30" textPosition="357 667" /> <org.gk.render.RenderableCompartment id="42" reactomeId="459" position="283 620" bounds="10 11 547 1219" textPosition="46 918" bgColor="250 240 240" lineColor="255 153 102" insets="21 28 528 1187"> <Properties> <displayName>cytoplasm</displayName> </Properties> <Components> <Component id="10" /> <Component id="11" /> <Component id="12" /> <Component id="13" /> <Component id="14" /> <Component id="15" /> <Component id="16" /> <Component id="17" /> <Component id="19" /> <Component id="20" /> <Component id="21" /> <Component id="23" /> <Component id="24" /> <Component id="25" /> <Component id="26" /> <Component id="27" /> <Component id="28" /> <Component id="29" /> <Component id="30" /> <Component id="31" /> <Component id="32" /> <Component id="33" /> <Component id="38" /> <Component id="40" /> <Component id="18" /> <Component id="34" /> <Component id="35" /> <Component id="36" /> <Component id="37" /> <Component id="43" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableEntitySet id="43" reactomeId="5276979" position="141 418" bounds="89 400 105 36" textPosition="89 400"> <Properties> <displayName>isopropylmalate isomerase</displayName> </Properties> </org.gk.render.RenderableEntitySet> </Nodes> <Edges> <org.gk.render.RenderableReaction id="10" reactomeId="5268272" points="307 129, 308 165, 308 209" position="308 165" lineWidth="1.0"> <Inputs> <Input id="11" points="374 104" /> <Input id="12" points="352 133" /> <Input id="13" points="307 102" /> </Inputs> <Outputs> <Output id="14" points="356 195" /> <Output id="15" points="308 246" /> <Output id="16" points="345 221" /> </Outputs> <Catalysts> <Catalyst id="17" points="214 165" /> </Catalysts> <Inhibitors> <Inhibitor id="18" points="348 1130, 420 1129, 418 166" /> </Inhibitors> <Properties> <displayName>3-methyl-2-oxobutanoate+acetyl-CoA+H2O-&gt;H++(2S)-2-isopropylmalate+coenzyme A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="19" reactomeId="5268274" points="308 296, 308 333, 308 366" position="308 333" lineWidth="1.0"> <Inputs> <Input id="15" /> </Inputs> <Outputs> <Output id="20" points="349 370" /> <Output id="21" points="308 400" /> </Outputs> <Catalysts> <Catalyst id="43" points="176 394" /> </Catalysts> <Properties> <displayName>(2S)-2-isopropylmalate-&gt;2-isopropylmaleate+H2O</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="23" reactomeId="5679622" points="308 457, 308 511, 308 558" position="308 511" lineWidth="1.0"> <Inputs> <Input id="24" points="344 454" /> <Input id="21" points="308 436" /> </Inputs> <Outputs> <Output id="25" /> </Outputs> <Catalysts> <Catalyst id="43" points="173 442" /> </Catalysts> <Properties> <displayName>Hydrolysis of 2-isopropylmaleate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="26" reactomeId="5268645" points="308 631, 308 660, 308 698" position="308 660" lineWidth="1.0"> <Inputs> <Input id="25" points="308 608" /> <Input id="27" points="339 625" /> </Inputs> <Outputs> <Output id="28" points="308 728" /> <Output id="29" points="349 709" /> <Output id="40" points="349 683" /> </Outputs> <Catalysts> <Catalyst id="30" points="208 660" /> </Catalysts> <Properties> <displayName>(2R,3S)-3-isopropylmalate+NAD+-&gt;(2S)-2-isopropyl-3-oxosuccinate+NADH+H+</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="31" reactomeId="5268648" points="308 797, 308 849, 307 882" position="308 849" lineWidth="1.0"> <Inputs> <Input id="28" points="308 778" /> <Input id="38" points="349 792" /> </Inputs> <Outputs> <Output id="32" points="307 915" /> <Output id="33" points="344 891" /> </Outputs> <Properties> <displayName>H++(2S)-2-isopropyl-3-oxosuccinate-&gt;4-methyl-2-oxopentanoate+CO2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="34" reactomeId="5679624" points="305 996, 306 1031, 306 1072" position="306 1031" lineWidth="1.0"> <Inputs> <Input id="32" points="306 967" /> <Input id="35" points="338 986" /> </Inputs> <Outputs> <Output id="18" points="307 1113" /> <Output id="36" points="339 1085" /> </Outputs> <Catalysts> <Catalyst id="37" points="207 1029" /> </Catalysts> <Inhibitors> <Inhibitor id="36" points="363 1076, 363 1030" /> </Inhibitors> <Properties> <displayName>L-glutamate+4-methyl-2-oxopentanoate-&gt;L-leucine+2-oxoglutarate</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
width565
[Change default viewing format]
No pathways have been reviewed or authored by Diagram of leucine biosynthesis (5679628)