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Details on Person ULK1 phosphorylates Beclin-1

Class:IdReaction:5679205
_displayNameULK1 phosphorylates Beclin-1
_doReleaseTRUE
_timestamp2020-04-02 10:42:42
authored[InstanceEdit:5671581] Jupe, Steve, 2015-02-02
catalystActivity[CatalystActivity:1632861] protein serine/threonine kinase activity of p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:5679261] Jupe, Steve, 2015-03-03
edited[InstanceEdit:5692984] Jupe, Steve, 2015-05-13
input[Complex:5683379] Beclin-1 complex [endoplasmic reticulum membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:5679238] ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
modified[InstanceEdit:5682408] Jupe, Steve, 2015-03-06
[InstanceEdit:5683339] Jupe, Steve, 2015-03-13
[InstanceEdit:5683378] Jupe, Steve, 2015-03-13
[InstanceEdit:5683719] Jupe, Steve, 2015-03-16
[InstanceEdit:5692976] Jupe, Steve, 2015-05-13
[InstanceEdit:5693009] Jupe, Steve, 2015-05-13
[InstanceEdit:6793655] Jupe, Steve, 2015-09-03
[InstanceEdit:9612935] Varusai, Thawfeek, 2018-07-05
[InstanceEdit:9638325] Varusai, Thawfeek, 2019-03-05
[InstanceEdit:9681506] Varusai, Thawfeek, 2020-04-02
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameULK1 phosphorylates Beclin-1
output[Complex:5679242] ATG14:PIK3C3:PIK3R4:p-S15-BECN1 [endoplasmic reticulum membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2015-06-17
reviewed[InstanceEdit:5693008] Tooze, Sharon A, 2015-05-13
[InstanceEdit:6793656] Klionsky, Daniel J, 2015-09-03
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:9638297] Varusai, Thawfeek, 2019-03-05
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5695775] R-HSA-5679205.6
summation[Summation:5679199] Following amino-acid starvation or mTOR inhibition, activate...
(hasEvent)[Pathway:1632852] Macroautophagy [Homo sapiens]
(precedingEvent)[Reaction:5672012] Beclin-1 complex phosphorylates PtdIns [Homo sapiens]
[BlackBoxEvent:5682385] The phagophore extends from the PIP3-enriched structure [Homo sapiens]
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No pathways have been reviewed or authored by ULK1 phosphorylates Beclin-1 (5679205)