Query author contributions in Reactome
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Details on Person Following amino-acid starvation or mTOR inhibition, activate...
| Class:Id | Summation:5679199 |
|---|---|
| _displayName | Following amino-acid starvation or mTOR inhibition, activate... |
| _timestamp | 2015-03-06 16:01:42 |
| created | [InstanceEdit:5679261] Jupe, Steve, 2015-03-03 |
| literatureReference | [LiteratureReference:5679238] ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase |
| modified | [InstanceEdit:5682408] Jupe, Steve, 2015-03-06 |
| text | Following amino-acid starvation or mTOR inhibition, activated ULK1 phosphorylates BECN1 (Beclin-1) on Ser-15, thereby enhancing the activity of PIK3C3 (Vps34) in the Beclin-1 complex. This phosphorylation is required for full autophagic induction in mammals (Russell et al. 2013). |
| (summation) | [Reaction:5679205] ULK1 phosphorylates Beclin-1 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Following amino-acid starvation or mTOR inhibition, activate... (5679199)
