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Details on Person Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region

Class:Id	Reaction:5678992
_displayName	Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region
_doRelease	TRUE
_timestamp	2020-08-24 13:28:10
authored	[InstanceEdit:5679004] Jassal, Bijay, 2015-02-27
catalystActivity	[CatalystActivity:5678994] chloride transmembrane transporter activity of Ivacaftor:CFTR G551D [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5678993] Jassal, Bijay, 2015-02-27
disease	[Disease:5678942] cystic fibrosis
edited	[InstanceEdit:5679004] Jassal, Bijay, 2015-02-27
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:352022] Cl- [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5678772] A CFTR potentiator in patients with cystic fibrosis and the G551D mutation [LiteratureReference:5678970] Ivacaftor: a novel mutation modulating drug [LiteratureReference:5678827] Drug bests cystic-fibrosis mutation [LiteratureReference:5678792] Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation
modified	[InstanceEdit:5679004] Jassal, Bijay, 2015-02-27 [InstanceEdit:5684033] Jassal, Bijay, 2015-03-18 [InstanceEdit:5690295] Jassal, Bijay, 2015-04-28 [InstanceEdit:9674652] Murillo, Julieth, 2020-01-17 [InstanceEdit:9698128] Jassal, Bijay, 2020-08-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region
normalReaction	[Reaction:5678863] CFTR transports Cl- from cytosol to extracellular region [Homo sapiens]
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:188972] Cl- [extracellular region] [SimpleEntity:29372] Pi [cytosol]
releaseDate	2015-06-17
releaseStatus	NEW
reviewed	[InstanceEdit:5690296] Moitra, Karobi, 2015-04-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695773] R-HSA-5678992.4
summation	[Summation:5678989] Cystic fibrosis transmembrane conductance regulator (CFTR) i...
(hasEvent)	[Pathway:5678895] Defective CFTR causes cystic fibrosis [Homo sapiens]
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No pathways have been reviewed or authored by Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region (5678992)