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Details on Person CFTR transports Cl- from cytosol to extracellular region

Class:Id	Reaction:5678863
_displayName	CFTR transports Cl- from cytosol to extracellular region
_doRelease	TRUE
_timestamp	2016-04-04 17:32:27
authored	[InstanceEdit:5678752] Jassal, Bijay, 2015-02-26
catalystActivity	[CatalystActivity:5678923] chloride transmembrane transporter activity of CFTR [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5678752] Jassal, Bijay, 2015-02-26
edited	[InstanceEdit:5678752] Jassal, Bijay, 2015-02-26
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:352022] Cl- [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5678961] Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA [LiteratureReference:5678960] CFTR and TMEM16A are separate but functionally related Cl- channels
modified	[InstanceEdit:5678957] Jassal, Bijay, 2015-02-27 [InstanceEdit:6793652] Jassal, Bijay, 2015-09-03 [InstanceEdit:8866862] Rothfels, Karen, 2016-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CFTR transports Cl- from cytosol to extracellular region
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:188972] Cl- [extracellular region] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[BlackBoxEvent:8866851] CFTR transits to the plasma membrane [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:5690296] Moitra, Karobi, 2015-04-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796671] R-HSA-5678863.3
summation	[Summation:5678848] Cystic fibrosis transmembrane conductance regulator (CFTR) i...
(hasEvent)	[Pathway:382556] ABC-family protein mediated transport [Homo sapiens]
(normalReaction)	[FailedReaction:5678822] Defective CFTR does not transport Cl- from cytosol to extracellular region [Homo sapiens] [Reaction:5678992] Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region [Homo sapiens]
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No pathways have been reviewed or authored by CFTR transports Cl- from cytosol to extracellular region (5678863)