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Details on Person KCNJ11:ABCC9 transports K+ from extracellular region to cytosol

Class:Id	Reaction:5678261
_displayName	KCNJ11:ABCC9 transports K+ from extracellular region to cytosol
_doRelease	TRUE
_timestamp	2026-02-27 21:18:30
authored	[InstanceEdit:5678262] Jassal, Bijay, 2015-02-23 [InstanceEdit:9977629] Gesino, Anthony, 2025-08-19 [InstanceEdit:9977627] Vaglio, Arielle, 2025-08-19
catalystActivity	[CatalystActivity:5678258] inward rectifier potassium channel activity of KCNJ11:ABCC9 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5678262] Jassal, Bijay, 2015-02-23
edited	[InstanceEdit:5678262] Jassal, Bijay, 2015-02-23
input	[SimpleEntity:74126] K+ [extracellular region]
internalReviewed	[InstanceEdit:9978791] Matthews, Lisa, 2026-01-07
isChimeric	FALSE
literatureReference	[LiteratureReference:5678259] Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells [LiteratureReference:5678266] A mutation in the ATP-binding site of the Kir6.2 subunit of the KATP channel alters coupling with the SUR2A subunit
modified	[InstanceEdit:5678752] Jassal, Bijay, 2015-02-26 [InstanceEdit:5693198] Jassal, Bijay, 2015-05-14 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9977624] Matthews, Lisa, 2025-12-22 [InstanceEdit:9983893] Matthews, Lisa, 2026-02-27
name	KCNJ11:ABCC9 transports K+ from extracellular region to cytosol
output	[SimpleEntity:29804] K+ [cytosol]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[PositiveRegulation:9977622] Positive regulation by 'KCNJ11:ABCC9:nicorandil [plasma membrane]'
regulationReference	[RegulationReference:9977632] Positive regulation by 'KCNJ11:ABCC9:nicorandil [plasma membrane]' ATP-Sensitive K+ channel modulator binding to sulfonylurea receptors SUR2A and SUR2B: opposite effects of MgADP
releaseDate	2014-03-12
reviewed	[InstanceEdit:5690296] Moitra, Karobi, 2015-04-28
reviewStatus	[ReviewStatus:9821385] four stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695769] R-HSA-5678261.4
structureModified	[InstanceEdit:9977624] Matthews, Lisa, 2025-12-22
summation	[Summation:5678257] ATP-sensitive inward rectifier potassium channel 11 (KCNJ11)...
(hasEvent)	[Pathway:382556] ABC-family protein mediated transport [Homo sapiens] [Pathway:5578775] Ion homeostasis [Homo sapiens]
(normalReaction)	[FailedReaction:5678418] Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9984706] Update Tracker - [Reaction:5678261] KCNJ11:ABCC9 transports K+ from extracellular region to cytosol - v96:[removeRegulator]
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