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Details on Person Methionine Sulfoxide Reductase B (MSRBs) are able to reduce ...

Class:IdSummation:5676945
_displayNameMethionine Sulfoxide Reductase B (MSRBs) are able to reduce ...
_timestamp2015-10-05 09:21:27
created[InstanceEdit:5676910] Jupe, Steve, 2015-02-20
literatureReference[LiteratureReference:5684947] Repair of oxidized proteins. Identification of a new methionine sulfoxide reductase
[LiteratureReference:5684916] Functions and evolution of selenoprotein methionine sulfoxide reductases
[LiteratureReference:5684924] New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements
[LiteratureReference:5684938] Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases
[LiteratureReference:5676915] Activity, tissue distribution and site-directed mutagenesis of a human peptide methionine sulfoxide reductase of type B: hCBS1
[LiteratureReference:5684923] Characterization of mouse endoplasmic reticulum methionine-R-sulfoxide reductase
[LiteratureReference:5676924] Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals
modified[InstanceEdit:5684935] Jupe, Steve, 2015-03-24
[InstanceEdit:5687525] Jupe, Steve, 2015-04-08
[InstanceEdit:6803158] Jupe, Steve, 2015-10-05
textMethionine Sulfoxide Reductase B (MSRBs) are able to reduce methyl-(R)-S-oxide to methionine (Grimaud et al. 2001). They are specific for the reduction of protein-based methyl-(R)-S-oxide, reducing free methyl-(R)-S-oxide with very low efficiency (Lee et al. 2009). Mammals have at least 3 MSRB genes (Kryukov et al. 1999, Huang et al. 1999, Jung et al. 2002, Kim & Gladyshev 2004). They are ubiquitously expressed, no clear substrate specificities are known, all three contain a zinc atom and can use thioredoxin as an in vivo reducing agent (Kim & Gladyshev 2007).
(summation)[Reaction:5676917] MRSBs reduce L-methyl-(R)-S-oxide to L-methionine [Homo sapiens]
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