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Details on Person Diagram of NIK-->noncanonical NF-kB signaling

Class:IdPathwayDiagram:5676610
_displayNameDiagram of NIK-->noncanonical NF-kB signaling
_timestamp2022-05-13 16:51:32
created[InstanceEdit:5676601] Garapati, Phani Vijay, 2015-02-20
height803
modified[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:9645116] Wu, G, 2019-05-03
[InstanceEdit:9645199] D'Eustachio, Peter, 2019-05-06
[InstanceEdit:9645201] D'Eustachio, Peter, 2019-05-06
[InstanceEdit:9645322] Matthews, Lisa, 2019-05-08
[InstanceEdit:9658436] Gupta, Parul, 2019-08-14
[InstanceEdit:9667325] Matthews, Lisa, 2019-11-11
[InstanceEdit:9689802] Matthews, Lisa, 2020-05-21
[InstanceEdit:9758633] Matthews, Lisa, 2021-11-21
[InstanceEdit:9774086] Matthews, Lisa, 2022-05-13
representedPathway[Pathway:5676590] NIK-->noncanonical NF-kB signaling [Homo sapiens]
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reactomeId="5607679" position="566 697" bounds="533 686 67 22" textPosition="534 686" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p52:RELB</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="37" reactomeId="70101" position="511 407" bounds="104 20 815 775" textPosition="503 274" bgColor="250 240 240" lineColor="255 153 102" insets="113 29 794 754"> <Properties> <displayName>cytosol</displayName> </Properties> <Components> <Component id="30" /> <Component id="31" /> <Component id="32" /> <Component id="33" /> <Component id="1" /> <Component id="2" /> <Component id="3" /> <Component id="4" /> <Component id="5" /> <Component id="6" /> <Component id="7" /> <Component id="8" /> <Component id="9" /> <Component id="10" /> <Component id="11" /> <Component id="12" /> <Component id="14" /> <Component id="34" /> <Component id="13" /> <Component id="15" /> <Component id="16" /> <Component id="17" /> <Component id="18" 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position="260 156" lineWidth="1.0"> <Inputs> <Input id="2" /> </Inputs> <Outputs> <Output id="3" /> </Outputs> <Properties> <displayName>Activation of NIK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4" reactomeId="5668545" points="333 99, 364 99, 394 99" position="364 99" lineWidth="1.0"> <Inputs> <Input id="5" points="314 79" /> <Input id="2" points="297 99" /> </Inputs> <Outputs> <Output id="6" points="367 201" /> <Output id="7" points="427 99" /> </Outputs> <Catalysts> <Catalyst id="2" points="260 85, 260 40, 363 40" /> </Catalysts> <Properties> <displayName>NIK autophosphorylates on T559</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="8" reactomeId="5607722" points="225 313, 261 313, 296 313" position="261 313" lineWidth="1.0"> <Inputs> <Input id="9" stoichiometry="4" points="190 286" /> <Input id="3" points="257 228" /> <Input id="10" points="197 347" /> </Inputs> <Outputs> <Output id="11" points="334 340" /> <Output id="12" stoichiometry="4" points="333 287" /> </Outputs> <Catalysts> <Catalyst id="3" points="261 228" /> </Catalysts> <Properties> <displayName>Active NIK phosphorylates IKKA dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="13" reactomeId="5607720" points="445 359, 475 359, 505 359" position="475 359" lineWidth="1.0"> <Inputs> <Input id="11" points="420 359" /> <Input id="14" points="429 331" /> </Inputs> <Outputs> <Output id="15" /> </Outputs> <Properties> <displayName>p100:RELB binds active NIK:p-IKKA dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="16" reactomeId="5607726" points="666 361, 695 364, 721 363" position="695 364" lineWidth="1.0"> <Inputs> <Input id="17" stoichiometry="7" points="647 322" /> <Input id="15" points="631 361" /> </Inputs> <Outputs> <Output id="18" points="750 364" /> <Output id="19" stoichiometry="7" points="738 324" /> </Outputs> <Catalysts> <Catalyst id="15" points="631 377, 693 395" /> </Catalysts> <Properties> <displayName>Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="20" reactomeId="5607723" points="763 438, 788 463, 800 521" position="788 463" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="18" points="797 396" /> <Input id="21" points="518 408" /> </Inputs> <Outputs> <Output id="22" /> </Outputs> <Properties> <displayName>SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="26" reactomeId="5607725" points="637 548, 574 548, 494 547" position="574 548" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="27" stoichiometry="4" points="686 521" /> <Input id="22" points="739 552" /> <Input id="28" points="591 491" /> <Input id="29" points="671 573" /> </Inputs> <Outputs> <Output id="21" points="467 417" /> <Output id="30" points="451 552" /> <Output id="11" points="370 382" /> <Output id="41" points="393 500" /> <Output id="28" points="558 491" /> </Outputs> <Catalysts> <Catalyst id="22" points="775 591, 739 626, 575 625" /> </Catalysts> <Properties> <displayName>SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="31" reactomeId="5607731" points="322 558, 283 558, 256 558" position="283 558" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="30" /> </Inputs> <Outputs> <Output id="32" stoichiometry="4" points="208 557" /> <Output id="33" points="311 612" /> </Outputs> <Catalysts> <Catalyst id="34" points="280 501" /> </Catalysts> <Properties> <displayName>26S proteasome processes p-7S-p100:RELB to form p52:RELB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="35" reactomeId="5607741" points="359 635, 440 661, 530 687" position="440 661" lineWidth="1.0"> <Inputs> <Input id="33" /> </Inputs> <Outputs> <Output id="36" /> </Outputs> <Properties> <displayName>p52:RELB translocates from cytosol to nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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