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Details on Person TRAFs bind RANK:RANKL

Class:Id	Reaction:5676595
_displayName	TRAFs bind RANK:RANKL
_doRelease	TRUE
_timestamp	2015-05-25 03:48:56
authored	[InstanceEdit:5668484] Garapati, Phani Vijay, 2015-01-26
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5676588] Garapati, Phani Vijay, 2015-02-20
edited	[InstanceEdit:5668484] Garapati, Phani Vijay, 2015-01-26
entityOnOtherCell	[DefinedSet:5676542] RANKL,sRANKL trimer [plasma membrane] [Homo sapiens]
input	[Complex:5676546] 3xRANK:RANKL,sRANKL trimer [plasma membrane] [Homo sapiens] [Complex:5668435] cIAP1,2:TRAF2:TRAF3:NIK [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5676476] TRAF2 is essential for TNF-alpha-induced osteoclastogenesis [LiteratureReference:5676411] The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily
modified	[InstanceEdit:5676601] Garapati, Phani Vijay, 2015-02-20 [InstanceEdit:5692511] Garapati, Phani Vijay, 2015-05-12 [InstanceEdit:5692519] Garapati, Phani Vijay, 2015-05-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRAFs bind RANK:RANKL
output	[Complex:5676557] 3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5676592] 2xRANK binds RANKL,sRANKL trimer:RANK [Homo sapiens] [Reaction:5676589] RANKL,sRANKL trimer binds RANK [Homo sapiens]
releaseDate	2015-06-17
releaseStatus	NEW
reviewed	[InstanceEdit:5692509] Ware, Carl F, Virgen-Slane, Richard, Rajput, Akhil, 2015-05-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695763] R-HSA-5676595.2
summation	[Summation:5676371] Upon activation, RANK on osteoclasts sends signals into the ...
(hasEvent)	[Pathway:5676594] TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway [Homo sapiens]
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No pathways have been reviewed or authored by TRAFs bind RANK:RANKL (5676595)