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Details on Person TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR

Class:Id	Reaction:5676593
_displayName	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR
_doRelease	TRUE
_timestamp	2015-05-25 03:48:56
authored	[InstanceEdit:5668484] Garapati, Phani Vijay, 2015-01-26
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5676588] Garapati, Phani Vijay, 2015-02-20
edited	[InstanceEdit:5668484] Garapati, Phani Vijay, 2015-01-26
entityOnOtherCell	[DefinedSet:5668763] lymphotoxin,TNFSF14 trimer [plasma membrane] [Homo sapiens]
input	[Complex:5676545] 3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] [Homo sapiens] [Complex:5668435] cIAP1,2:TRAF2:TRAF3:NIK [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5676419] Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB [LiteratureReference:5676318] TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor [LiteratureReference:5676521] Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis
modified	[InstanceEdit:5676601] Garapati, Phani Vijay, 2015-02-20 [InstanceEdit:5692511] Garapati, Phani Vijay, 2015-05-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR
output	[Complex:5676558] 3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5676591] 2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer [Homo sapiens] [Reaction:5668789] LA,TNFSF14 binds LTBR [Homo sapiens]
releaseDate	2015-06-17
releaseStatus	NEW
reviewed	[InstanceEdit:5692509] Ware, Carl F, Virgen-Slane, Richard, Rajput, Akhil, 2015-05-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695762] R-HSA-5676593.2
summation	[Summation:5676256] After clustering or dimerisation lymphotoxin-beta receptor (...
(hasEvent)	[Pathway:5676594] TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway [Homo sapiens]
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No pathways have been reviewed or authored by TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (5676593)