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Details on Person B cell activating factor of the TNF family (BAFF, also known...
| Class:Id | Summation:5676474 |
|---|---|
| _displayName | B cell activating factor of the TNF family (BAFF, also known... |
| _timestamp | 2015-03-17 16:56:29 |
| created | [InstanceEdit:5676482] Garapati, Phani Vijay, 2015-02-19 |
| literatureReference | [LiteratureReference:5676373] Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands [LiteratureReference:5676394] Ligand-receptor binding revealed by the TNF family member TALL-1 [LiteratureReference:5676252] An atypical tumor necrosis factor (TNF) receptor-associated factor-binding motif of B cell-activating factor belonging to the TNF family (BAFF) receptor mediates induction of the noncanonical NF-kappaB signaling pathway [LiteratureReference:5676480] BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses [LiteratureReference:5676454] TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease [LiteratureReference:5676279] Cracking the BAFF code [LiteratureReference:5676449] Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion |
| modified | [InstanceEdit:5683949] Garapati, Phani Vijay, 2015-03-17 |
| text | B cell activating factor of the TNF family (BAFF, also known as TNFSF13B) is a type II transmembrane protein that binds and predominantly activates its receptor BAFFR (TNFRSF13C) to transmit survival and growth signals to B cells (Li et al. 2008). BAFF is the most critical soluble factor for peripheral B-cell maturation and survival. BAFF is expressed by T cells, macrophages and dendritic cells, but not B cells. BAFF is primarily synthesised as membrane-bound but is proteolytically processed at furin consensus sequence to produce soluble protein. Processed, soluble BAFF adopts a usual trimeric form that appears to be the primary bioactive form of BAFF, but it is the only member of the family that can also further assemble as an ordered, capsid-like structure comprising twenty trimers. A trimeric BAFF ligand binds to three independent BAFFR (TNFRSF13C) receptor to initiate signalling (Liu et al. 2002, 2003, Mackay & Schneider 2009). BAFFR is predominantly expressed in B cells and contains a typical TNF receptor-associated factor (TRAF)-binding sites in their cytoplasmic domains which interacts with TRAF3 but not TRAF2 upon ligand interaction (Morrison et al. 2005). BAFF can also bind to other TNF superfamily (TNFSF) members, B cell maturation antigen (BCMA also known as TNFRSF17) and transmembrane activator and CAML interactor (TAC also known as TNFRSF13B) (Gross et al. 2000). |
| (summation) | [Reaction:5676599] sBAFF trimer binds BAFFR [Homo sapiens] |
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