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Details on Person The FN14 (TNFRSF12A) intracellular domain lacks the characte...
| Class:Id | Summation:5676429 |
|---|---|
| _displayName | The FN14 (TNFRSF12A) intracellular domain lacks the characte... |
| _timestamp | 2015-03-17 16:56:35 |
| created | [InstanceEdit:5676482] Garapati, Phani Vijay, 2015-02-19 |
| literatureReference | [LiteratureReference:5676305] TWEAK activates the non-canonical NFkappaB pathway in murine renal tubular cells: modulation of CCL21 [LiteratureReference:5676251] TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation [LiteratureReference:5676481] TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha [LiteratureReference:5676414] The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation [LiteratureReference:5676289] TWEAK/Fn14 and Non-Canonical NF-kappaB Signaling in Kidney Disease |
| modified | [InstanceEdit:5683949] Garapati, Phani Vijay, 2015-03-17 |
| text | The FN14 (TNFRSF12A) intracellular domain lacks the characteristic death domain of TNF receptor superfamily (TNFRSF) but contains TNFR-associated factor (TRAF) binding sites. Upon TWEAK binding, FN14 recruits TRAF2 and TRAF3 to activate both canonical and non-canonical nuclear factor-kappa B (NF-kB) pathway (Brown et al. 2003, Saitoh et al. 2003, Sanz et al. 2010). NF-kB activation plays a key role in TWEAK-elicited inflammatory responses. TWEAK/FN14 binding induces NIK activation through targeting the degradation of TRAF2/cellular inhibitor of apoptosis (cIAP) 1 and 2 complex (Vince et al. 2008). TWEAK activation of the non-canonical NF-kB pathways promotes inflammatory responses in tubular cells. In cultured renal tubular cells TWEAK increases nuclear RelB/p52 accumulation, RelB and p52 DNA-binding activity, and NIK- and RelB-dependent CCL21 and CCL19 expression (Poveda et al. 2010). |
| (summation) | [Reaction:5676598] TRAF2:cIAP1/2 complex binds FN14:TWEAK [Homo sapiens] |
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No pathways have been reviewed or authored by The FN14 (TNFRSF12A) intracellular domain lacks the characte... (5676429)
