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Details on Person Receptor activator of the NF-kB (RANK also known as TNFRSF11...
| Class:Id | Summation:5676390 |
|---|---|
| _displayName | Receptor activator of the NF-kB (RANK also known as TNFRSF11... |
| _timestamp | 2015-02-19 18:35:00 |
| created | [InstanceEdit:5676482] Garapati, Phani Vijay, 2015-02-19 |
| literatureReference | [LiteratureReference:5676440] RANK-L and RANK: T cells, bone loss, and mammalian evolution [LiteratureReference:5676294] Structural and functional insights of RANKL-RANK interaction and signaling [LiteratureReference:5668539] Non-canonical NF-kB signaling pathway [LiteratureReference:5675753] RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis |
| text | Receptor activator of the NF-kB (RANK also known as TNFRSF11A) is a type I transmembrane protein expressed on osteoclast precursors, dendritic cells and activated B cells, and in general RANK signalling promotes cell survival and differentiation. RANK and its ligand RANKL (TNFSF11) are key regulators of bone remodeling, and they are essential for the development and activation of osteoclasts (Nakagawa et al. 1998). RANK/RANKL interaction also regulates important immune functions, such as dendritic cell survival and lymphoid organogenesis (Sun 2011, Theill et al. 2002). RANKL (also known as TNFSF11) is a type II transmembrane protein, primarily expressed on the surface of activated T-cells, bone marrow stromal cells, and osteoblasts. Soluble form of RANKL (sRANKL) that arise from either proteolytic cleavage or alternative splicing have also been observed. Both the membrane bound and soluble forms of RANKL are assembled into functional homotrimers like other members of the TNFSF (Liu et al. 2010). |
| (summation) | [Reaction:5676589] RANKL,sRANKL trimer binds RANK [Homo sapiens] |
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No pathways have been reviewed or authored by Receptor activator of the NF-kB (RANK also known as TNFRSF11... (5676390)
