Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of Macroautophagy

Class:IdPathwayDiagram:5675705
_displayNameDiagram of Macroautophagy
_timestamp2025-01-25 20:34:03
created[InstanceEdit:5675706] Jupe, Steve, 2015-02-16
height1619
modified[InstanceEdit:5675792] Jupe, Steve, 2015-02-16
[InstanceEdit:5675857] Jupe, Steve, 2015-02-17
[InstanceEdit:5682408] Jupe, Steve, 2015-03-06
[InstanceEdit:5683339] Jupe, Steve, 2015-03-13
[InstanceEdit:5683378] Jupe, Steve, 2015-03-13
[InstanceEdit:5683380] Jupe, Steve, 2015-03-13
[InstanceEdit:5683589] Jupe, Steve, 2015-03-16
[InstanceEdit:5683639] Jupe, Steve, 2015-03-16
[InstanceEdit:5683719] Jupe, Steve, 2015-03-16
[InstanceEdit:5683812] Jupe, Steve, 2015-03-17
[InstanceEdit:5683921] Jupe, Steve, 2015-03-17
[InstanceEdit:5683947] Jupe, Steve, 2015-03-17
[InstanceEdit:5692976] Jupe, Steve, 2015-05-13
[InstanceEdit:5693049] Jupe, Steve, 2015-05-13
[InstanceEdit:5693824] Jupe, Steve, 2015-05-18
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8869055] Jupe, Steve, 2016-04-25
[InstanceEdit:9020618] Jupe, Steve, 2017-09-08
[InstanceEdit:9021304] Jupe, Steve, 2017-09-18
[InstanceEdit:9616905] D'Eustachio, Peter, 2018-08-15
[InstanceEdit:9634384] Varusai, Thawfeek, 2019-01-10
[InstanceEdit:9637871] Varusai, Thawfeek, 2019-02-21
[InstanceEdit:9645116] Wu, G, 2019-05-03
[InstanceEdit:9658415] D'Eustachio, Peter, 2019-08-13
[InstanceEdit:9663890] Varusai, Thawfeek, 2019-10-17
[InstanceEdit:9665499] Varusai, Thawfeek, 2019-10-31
[InstanceEdit:9820479] D'Eustachio, Peter, 2022-11-07
[InstanceEdit:9931255] Matthews, Lisa, 2024-12-11
[InstanceEdit:9936627] Orlic-Milacic, Marija, 2025-01-24
[InstanceEdit:9936736] Orlic-Milacic, Marija, 2025-01-25
[InstanceEdit:9936737] Orlic-Milacic, Marija, 2025-01-25
representedPathway[Pathway:1632852] Macroautophagy [Homo sapiens]
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textPosition="1907 1290" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LC3:PE</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="15367" reactomeId="917723" position="1950 956" bounds="1919 945 62 22" textPosition="1921 945" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ESCRT-III</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="15368" reactomeId="5683632" position="2054 1036" bounds="2001 1025 106 22" textPosition="2001 1025" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>UVRAG complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="15773" reactomeId="29372" position="523 658" bounds="510 643 27 30" textPosition="515 647"> <Properties> <displayName>Pi</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="16026" reactomeId="5671731" position="1354 892" bounds="1303 881 102 22" textPosition="1304 881"> <Properties> <displayName>ATG9A,(ATG9B)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="16130" reactomeId="5678301" position="1396 338" bounds="1337 320 119 36" textPosition="1340 320"> <Properties> <displayName>WIPI1,WIPI2,(WDR45,WDR45B)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="16131" reactomeId="5678302" position="1656 396" bounds="1589 377 135 39" textPosition="1593 380" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>WIPI1,WIPI2,(WDR45,WDR45B):PI3P</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="16167" reactomeId="5692947" position="1380 1048" bounds="1329 1037 103 22" textPosition="1335 1037" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>WIPI2:PI(3,5)P2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="17922" reactomeId="5693050" position="1388 402" bounds="1368 387 41 30" textPosition="1373 391"> <Properties> <displayName>PI3P</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableCompartment id="17926" reactomeId="161320" position="787 279" bounds="447 130 680 298" textPosition="729 262" bgColor="250 240 240" lineColor="255 153 102" insets="457 140 658 278"> <Properties> <displayName>lysosomal lumen</displayName> </Properties> <Components> <Component id="10" /> <Component id="12" /> <Component id="139" /> <Component id="7" /> <Component id="372" /> <Component id="582" /> <Component id="1135" /> <Component id="1138" /> <Component id="1136" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="17927" reactomeId="9020617" position="132 1227" bounds="70 1216 125 22" textPosition="71 1216" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ATG12:ATG7 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="17929" reactomeId="113592" position="352 266" bounds="332 251 40 30" textPosition="337 255" /> <org.gk.render.RenderableChemical id="17930" reactomeId="29370" position="354 308" bounds="334 293 41 30" textPosition="338 297" /> <org.gk.render.ProcessNode id="18111" reactomeId="9663891" position="1212 1125" bounds="1139 1100 146 50" textPosition="1143 1110"> <Properties> <displayName>Selective autophagy</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="18121" reactomeId="9820408" position="478 1483" bounds="424 1465 109 37" textPosition="427 1466" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CysO572-ATG7-LC3:ATG7</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="18122" reactomeId="9820424" position="693 1482" bounds="639 1464 109 37" textPosition="641 1465" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CysO572-ATG7-LC3:ATG7:ATG3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="18131" reactomeId="9820425" position="888 1485" bounds="834 1467 109 37" textPosition="836 1468" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CysO264-ATG3-LC3:ATG7 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="18132" reactomeId="9819367" position="1251 1484" bounds="1186 1473 131 23" textPosition="1189 1473"> <Properties> <displayName>CysO264-ATG3-LC3</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="18133" reactomeId="9936619" position="1355 1180" bounds="1320 1170 71 21" textPosition="1324 1170"> <Properties> <displayName>ATG16L2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="18143" reactomeId="9936621" position="1385 1251" bounds="1334 1233 103 37" textPosition="1340 1234" bgColor="204 255 255" hideComponents="true" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="2" reactomeId="5672011" points="122 382, 122 439, 119 508" position="122 439" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="590 509" /> <Input id="4" points="132 152" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> <Properties> <displayName>p-AMPK:AMP binds the ULK complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="6" reactomeId="5672817" points="299 153, 300 185, 383 207" position="300 185" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="7" points="417 138" /> <Input id="4" points="194 137" /> </Inputs> <Outputs> <Output id="139" /> </Outputs> <Properties> <displayName>Active MTORC1 binds the ULK1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="10" reactomeId="5672010" points="450 273, 450 292, 450 308" position="450 292" lineWidth="1.0"> <Inputs> <Input id="139" points="450 253" /> <Input id="17929" points="375 267" /> </Inputs> <Outputs> <Output id="17930" points="378 308" /> <Output id="372" points="450 335" /> </Outputs> <Catalysts> <Catalyst id="139" points="473 253, 500 280" /> </Catalysts> <Properties> <displayName>Active MTORC1 phosphorylates ULK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="12" reactomeId="5672017" points="552 144, 681 173, 798 144" position="681 173" lineWidth="1.0"> <Inputs> <Input id="7" /> </Inputs> <Outputs> <Output id="582" /> </Outputs> <Catalysts> <Catalyst id="7" points="526 151, 681 214" /> </Catalysts> <Activators> <Activator id="13" points="681 123" /> </Activators> <Properties> <displayName>Rheb in the MTORC1 complex hydrolyses GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14" reactomeId="5665868" points="194 612, 221 613, 251 612" position="221 613" lineWidth="1.0"> <Inputs> <Input id="5" points="155 581" /> <Input id="15" stoichiometry="5" points="167 652" /> </Inputs> <Outputs> <Output id="16" points="290 583" /> <Output id="17" stoichiometry="5" points="280 665" /> </Outputs> <Catalysts> <Catalyst id="5" points="189 569, 220 582" /> </Catalysts> <Properties> <displayName>AMPK (complex) phosphorylates ULK1 (complex)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1132" reactomeId="5673768" points="619 443, 656 443, 688 443" position="656 443" lineWidth="1.0"> <Inputs> <Input id="1133" stoichiometry="2" points="600 456" /> <Input id="372" points="517 398" /> </Inputs> <Outputs> <Output id="1134" stoichiometry="2" points="713 461" /> <Output id="1135" points="735 426" /> </Outputs> <Catalysts> <Catalyst id="3" points="656 506" /> </Catalysts> <Properties> <displayName>p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1136" reactomeId="5675790" points="883 406, 918 408, 961 408" position="918 408" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="1135" /> </Inputs> <Outputs> <Output id="1137" points="780 582" /> <Output id="1138" points="1018 408" /> </Outputs> <Properties> <displayName>MTORC1 dissociates from ULK complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1546" reactomeId="5672008" points="363 610, 363 649, 363 679" position="363 649" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="16" points="360 589" /> <Input id="2179" points="346 611" /> </Inputs> <Outputs> <Output id="1547" points="384 701" /> <Output id="17" points="312 681" /> </Outputs> <Catalysts> <Catalyst id="16" points="377 589, 404 648" /> </Catalysts> <Properties> <displayName>Thr-180 of ULK1 is phosphorylated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2167" reactomeId="5675868" points="514 776, 534 776, 559 776" position="534 776" lineWidth="1.0"> <Inputs> <Input id="2193" stoichiometry="2" points="500 812" /> <Input id="1547" points="496 769" /> </Inputs> <Outputs> <Output id="2211" stoichiometry="2" points="577 810" /> <Output id="2171" points="599 766" /> </Outputs> <Catalysts> <Catalyst id="1547" points="496 748, 534 747" /> </Catalysts> <Properties> <displayName>ULK1 phosphorylates ATG13 and RB1CC1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="11527" reactomeId="1632843" points="236 877, 269 877, 317 877" position="269 877" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="11528" points="211 855" /> <Input id="11529" points="205 901" /> </Inputs> <Outputs> <Output id="11530" /> </Outputs> <Properties> <displayName>AMBRA1 binds DYNLL1,DYNLL2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="11531" reactomeId="5678313" points="425 912, 459 912, 511 912" position="459 912" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="11532" points="394 964" /> <Input id="11530" points="401 899" /> </Inputs> <Outputs> <Output id="11533" /> </Outputs> <Properties> <displayName>AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="11534" reactomeId="1632857" points="681 916, 682 956, 682 1011" position="682 956" lineWidth="1.0"> <Inputs> <Input id="11535" points="704 900" /> <Input id="11533" points="629 914" /> </Inputs> <Outputs> <Output id="11536" points="651 1024" /> <Output id="11537" points="710 1033" /> </Outputs> <Catalysts> <Catalyst id="11697" points="848 910" /> </Catalysts> <Properties> <displayName>ULK1 phosphorylates AMBRA1:BECN1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="11641" reactomeId="5678315" points="522 1047, 462 1046, 382 1046" position="462 1046" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="11536" /> </Inputs> <Outputs> <Output id="11532" points="383 1006" /> <Output id="11642" points="350 1069" /> <Output id="11529" points="210 935" /> </Outputs> <Properties> <displayName>BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="11643" reactomeId="5679266" points="431 985, 772 988, 865 989" position="772 988" lineWidth="1.0"> <Inputs> <Input id="11532" /> </Inputs> <Outputs> <Output id="11788" /> </Outputs> <Properties> <displayName>Beclin-1 complex translocates to the ER</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="11646" reactomeId="5672012" points="972 782, 1010 783, 1046 783" position="1010 783" lineWidth="1.0"> <Inputs> <Input id="11647" points="959 796" /> <Input id="11648" points="950 767" /> </Inputs> <Outputs> <Output id="11649" points="1064 767" /> <Output id="11650" points="1060 793" /> </Outputs> <Catalysts> <Catalyst id="11645" points="1153 964, 1011 843" /> </Catalysts> <Properties> <displayName>Beclin-1 complex phosphorylates PtdIns</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="11678" reactomeId="5682385" points="1251 992, 1284 993, 1316 992" position="1284 993" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="11645" /> </Inputs> <Outputs> <Output id="11679" /> </Outputs> <Activators> <Activator id="16026" points="1346 909" /> </Activators> <Properties> <displayName>The phagophore extends from the PIP3-enriched structure</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="11696" reactomeId="5679239" points="734 787, 777 813, 848 855" position="777 813" lineWidth="1.0"> <Inputs> <Input id="2171" /> </Inputs> <Outputs> <Output id="11697" /> </Outputs> <Properties> <displayName>ULK complex translocates to the ER</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="12119" reactomeId="5679206" points="1056 798, 1009 767, 959 799" position="1009 767" lineWidth="1.0"> <Inputs> <Input id="11650" /> </Inputs> <Outputs> <Output id="11647" /> </Outputs> <Catalysts> <Catalyst id="12120" points="1009 729" /> </Catalysts> <Properties> <displayName>MTMR14, MTMR3 dephosphorylate PI3P</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="12220" reactomeId="5679205" points="1005 992, 1040 993, 1073 992" position="1040 993" lineWidth="1.0"> <Inputs> <Input id="11788" points="978 991" /> <Input id="11902" points="977 1038" /> </Inputs> <Outputs> <Output id="11645" points="1113 992" /> <Output id="12222" points="1092 1035" /> </Outputs> <Catalysts> <Catalyst id="11697" points="970 940" /> </Catalysts> <Properties> <displayName>ULK1 phosphorylates Beclin-1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="12238" reactomeId="5681980" points="132 1286, 131 1270, 131 1241" position="131 1270" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="12239" points="110 1303" /> <Input id="12240" points="202 1304" /> </Inputs> <Outputs> <Output id="17927" /> </Outputs> <Properties> <displayName>ATG12 binds ATG7 dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="12242" reactomeId="5682893" points="387 1202, 416 1203, 458 1203" position="416 1203" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="12243" points="343 1172" /> <Input id="12241" points="351 1212" /> </Inputs> <Outputs> <Output id="12244" /> </Outputs> <Properties> <displayName>ATG12:ATG7:CysO572-ATG7 binds ATG10</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="12245" reactomeId="5681999" points="565 1204, 613 1204, 653 1204" position="613 1204" lineWidth="1.0"> <Inputs> <Input id="12244" /> </Inputs> <Outputs> <Output id="12387" /> </Outputs> <Catalysts> <Catalyst id="12244" points="565 1188, 612 1173" /> </Catalysts> <Properties> <displayName>ATG10 transfers ATG12 from ATG7 to ATG10</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="12793" reactomeId="5683583" points="718 1232, 731 1259, 750 1297" position="731 1259" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="12387" /> </Inputs> <Outputs> <Output id="12240" points="272 1312" /> <Output id="12526" points="789 1308" /> </Outputs> <Properties> <displayName>ATG10:ATG12:ATG7 dimer dissociates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="12809" reactomeId="5682010" points="925 1350, 956 1350, 989 1349" position="956 1350" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="12526" points="899 1340" /> <Input id="12810" points="888 1367" /> </Inputs> <Outputs> <Output id="12811" /> </Outputs> <Properties> <displayName>ATG10:ATG12 binds ATG5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15223" reactomeId="5683588" points="1100 1349, 1132 1349, 1167 1349" position="1132 1349" lineWidth="1.0"> <Inputs> <Input id="12811" /> </Inputs> <Outputs> <Output id="15224" /> </Outputs> <Properties> <displayName>ATG10 transfers ATG12 from ATG10 to ATG5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15225" reactomeId="5682690" points="1276 1347, 1308 1345, 1342 1345" position="1308 1345" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="15224" /> </Inputs> <Outputs> <Output id="15226" points="1385 1341" /> <Output id="12243" points="357 1156, 817 1156" /> </Outputs> <Properties> <displayName>ATG10 dissociates from ATG12:ATG5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15227" reactomeId="5682012" points="1462 1246, 1462 1186, 1462 1142" position="1462 1186" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="15226" stoichiometry="4" points="1441 1317" /> <Input id="15228" stoichiometry="4" points="1522 1326" /> </Inputs> <Outputs> <Output id="15229" /> </Outputs> <Inhibitors> <Inhibitor id="18133" points="1394 1181" /> </Inhibitors> <Properties> <displayName>ATG5:ATG12 binds ATG16L1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15230" reactomeId="5679255" points="1475 1076, 1494 1078, 1540 1067" position="1494 1078" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="16167" points="1417 1062" /> <Input id="15229" points="1467 1100" /> </Inputs> <Outputs> <Output id="15232" /> </Outputs> <Properties> <displayName>WIPI2 binds ATG12:ATG5:ATG16L</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15233" reactomeId="5681987" points="199 1551, 235 1551, 291 1551" position="235 1551" lineWidth="1.0"> <Inputs> <Input id="15234" /> </Inputs> <Outputs> <Output id="15235" /> </Outputs> <Catalysts> <Catalyst id="15236" points="236 1517" /> </Catalysts> <Properties> <displayName>LC3 is cleaved by ATG4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15237" reactomeId="5682011" points="358 1482, 386 1482, 421 1482" position="386 1482" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="12240" points="249 1334" /> <Input id="15235" points="338 1534" /> </Inputs> <Outputs> <Output id="18121" /> </Outputs> <Properties> <displayName>LC3 binds ATG7 dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15239" reactomeId="5682896" points="566 1481, 599 1481, 636 1481" position="599 1481" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="15240" points="516 1568" /> <Input id="18121" points="536 1481" /> </Inputs> <Outputs> <Output id="18122" /> </Outputs> <Properties> <displayName>LC3:ATG7 dimer binds ATG3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15242" reactomeId="5681981" points="751 1483, 789 1484, 831 1484" position="789 1484" lineWidth="1.0"> <Inputs> <Input id="18122" /> </Inputs> <Outputs> <Output id="18131" /> </Outputs> <Catalysts> <Catalyst id="18122" points="722 1504, 756 1521" /> </Catalysts> <Properties> <displayName>ATG3 transfers LC3 from ATG7 to ATG3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15244" reactomeId="5683593" points="946 1483, 983 1483, 1048 1485" position="983 1483" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="18131" /> </Inputs> <Outputs> <Output id="18132" points="1180 1484" /> <Output id="12240" points="272 1318, 981 1432" /> </Outputs> <Properties> <displayName>ATG7:ATG3:LC3 dissociates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15246" reactomeId="5678490" points="1430 1480, 1597 1432, 1675 1432" position="1597 1432" lineWidth="1.0"> <Inputs> <Input id="15247" points="1457 1435" /> <Input id="18132" points="1323 1482" /> </Inputs> <Outputs> <Output id="15248" points="1712 1070" /> <Output id="15240" points="537 1581, 1724 1571" /> </Outputs> <Catalysts> <Catalyst id="15232" points="1598 1067" /> </Catalysts> <Properties> <displayName>ATG16L1 complex transfers LC3 from ATG3 to PE</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15301" reactomeId="5682377" points="1712 1070, 1649 1461, 1555 1497" position="1649 1461" lineWidth="1.0"> <Inputs> <Input id="15248" /> </Inputs> <Outputs> <Output id="15247" points="1483 1429" /> <Output id="15235" points="379 1550, 1504 1542" /> </Outputs> <Catalysts> <Catalyst id="15303" points="1638 1503" /> </Catalysts> <Properties> <displayName>LC3 de-lipidation by ATG4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15365" reactomeId="5682388" points="1743 1055, 1927 1056, 1929 1287" position="1927 1056" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="15248" /> </Inputs> <Outputs> <Output id="15366" /> </Outputs> <Activators> <Activator id="15367" points="1947 970" /> <Activator id="15368" points="1998 1044" /> </Activators> <Properties> <displayName>Autophagosome maturation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15772" reactomeId="5683925" points="695 617, 617 618, 559 618" position="617 618" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="1137" /> </Inputs> <Outputs> <Output id="4" points="149 152" /> <Output id="15773" points="536 640" /> </Outputs> <Properties> <displayName>ULK1 is dephosphorylated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="16128" reactomeId="5676229" points="1473 372, 1545 371, 1586 380" position="1545 371" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="17922" points="1412 394" /> <Input id="16130" points="1436 362" /> </Inputs> <Outputs> <Output id="16131" /> </Outputs> <Properties> <displayName>WIPIs bind PI3P</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="17928" reactomeId="9020616" points="198 1227, 215 1228, 242 1227" position="215 1228" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="17927" /> </Inputs> <Outputs> <Output id="12241" /> </Outputs> <Properties> <displayName>ATG12 forms a thioester bond with ATG7 dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="18113" interactionType="Activate" points="1288 1123, 1420 1121" position="1354 1122" lineWidth="2.0"> <Inputs> <Input id="18111" /> </Inputs> <Outputs> <Output id="15229" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="18142" reactomeId="9936620" points="1228 1259, 1290 1253, 1331 1252" position="1290 1253" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="18133" points="1338 1194" /> <Input id="15226" points="1388 1317" /> </Inputs> <Outputs> <Output id="18143" /> </Outputs> <Properties> <displayName>ATG5:ATG12 binds ATG16L2</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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