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Details on Person Cytosolic DUSPs dephosphorylate MAPKs

Class:Id	Reaction:5675376
_displayName	Cytosolic DUSPs dephosphorylate MAPKs
_doRelease	TRUE
_timestamp	2019-02-13 10:34:41
authored	[InstanceEdit:5675264] Rothfels, Karen, 2015-02-15
catalystActivity	[CatalystActivity:5675370] protein tyrosine/serine/threonine phosphatase activity of cytosolic MAPK DUSPs [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5675378] Rothfels, Karen, 2015-02-15
edited	[InstanceEdit:5675264] Rothfels, Karen, 2015-02-15
input	[SimpleEntity:29356] H2O [cytosol] [DefinedSet:5674340] p-T,Y MAPK monomers and dimers [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5673943] ERK1/2 MAP kinases: structure, function, and regulation [LiteratureReference:5675330] The dual-specificity MAP kinase phosphatases: critical roles in development and cancer [LiteratureReference:5675326] Regulation of MAP kinases by MAP kinase phosphatases
modified	[InstanceEdit:5678362] Rothfels, Karen, 2015-02-23 [InstanceEdit:5690609] Rothfels, Karen, 2015-04-29 [InstanceEdit:5691226] Rothfels, Karen, 2015-05-05 [InstanceEdit:5692881] Rothfels, Karen, 2015-05-13 [InstanceEdit:9636562] Pardo, Agustin, 2019-02-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Cytosolic DUSPs dephosphorylate MAPKs
output	[SimpleEntity:29372] Pi [cytosol] [DefinedSet:5675361] MAPK monomers and dimers [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5674385] p-T,Y MAPKs dimerize [Homo sapiens] [Reaction:5672980] Dissociation of RAS:RAF complex [Homo sapiens] [Reaction:109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 [Homo sapiens] [BlackBoxEvent:109863] Dissociation of p-T,Y-MAPK3:MAP2K1 [Homo sapiens] [BlackBoxEvent:9610154] Dissociation of phosphorylated MAP2Ks and MAPKs [Homo sapiens]
releaseDate	2015-06-17
releaseStatus	NEW
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695749] R-HSA-5675376.3
summation	[Summation:5675377] MAPKs are inactivated by dephosphorylation of the activation...
(hasEvent)	[Pathway:112409] RAF-independent MAPK1/3 activation [Homo sapiens] [Pathway:5675221] Negative regulation of MAPK pathway [Homo sapiens]
(normalReaction)	[FailedReaction:9652816] Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs [Homo sapiens]
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No pathways have been reviewed or authored by Cytosolic DUSPs dephosphorylate MAPKs (5675376)