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Details on Person Dissociation of RAS:RAF complex

Class:Id	Reaction:5672980
_displayName	Dissociation of RAS:RAF complex
_doRelease	TRUE
_timestamp	2015-05-25 03:48:41
authored	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5672979] Rothfels, Karen, 2015-02-06
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
input	[Complex:5672724] activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5675138] Regulation of Ras localization by acylation enables a mode of intracellular signal propagation [LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks [LiteratureReference:5672144] "RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway [LiteratureReference:1497944] The RAF proteins take centre stage
modified	[InstanceEdit:5674063] Rothfels, Karen, 2015-02-10 [InstanceEdit:5675256] Rothfels, Karen, 2015-02-15 [InstanceEdit:5676978] Rothfels, Karen, 2015-02-20 [InstanceEdit:5678393] Rothfels, Karen, 2015-02-23 [InstanceEdit:5690608] Rothfels, Karen, 2015-04-29 [InstanceEdit:5691228] Rothfels, Karen, 2015-05-05 [InstanceEdit:5692882] Rothfels, Karen, 2015-05-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dissociation of RAS:RAF complex
output	[DefinedSet:169289] p-T,Y MAPKs [cytosol] [Homo sapiens] [CandidateSet:5672717] RAF/MAPK scaffolds [cytosol] [Homo sapiens] [DefinedSet:5672721] p-2S MAP2K homo/heterodimers [cytosol] [Homo sapiens] [Complex:5672712] p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5672973] MAP2Ks phosphorylate MAPKs [Homo sapiens] [Reaction:5672978] RAF phosphorylates MAP2K dimer [Homo sapiens]
releaseDate	2015-06-17
releaseStatus	NEW
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695734] R-HSA-5672980.2
summation	[Summation:5675211] The mechanisms governing the dissociation or trafficking of ...
(hasEvent)	[Pathway:5674135] MAP2K and MAPK activation [Homo sapiens]
(normalReaction)	[Reaction:6802932] Dissociation of BRAF/RAF fusion complex [Homo sapiens] [Reaction:6803227] Dissociation of high activity BRAF complexes [Homo sapiens] [Reaction:6803230] Dissociation of moderate activity BRAF complexes [Homo sapiens] [Reaction:6803233] Dissociation of oncogenic RAS:RAF complex [Homo sapiens] [Reaction:6803234] Dissociation of paradoxically activated RAS:BRAF complexes [Homo sapiens] [Reaction:9656209] Dissociation of RAS:RAF1 mutant complex [Homo sapiens]
(precedingEvent)	[Reaction:5674366] IL17RD binds p-2S MAP2Ks and MAPKs [Homo sapiens] [Reaction:5674385] p-T,Y MAPKs dimerize [Homo sapiens]
(replacementInstances)	[_Deleted:6799080] Deletion of instance: 1268206
(updatedInstance)	[_UpdateTracker:9782907] Update Tracker - [Reaction:5672980] Dissociation of RAS:RAF complex - v58:[modifyText]
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