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Details on Person MAP2Ks phosphorylate MAPKs

Class:Id	Reaction:5672973
_displayName	MAP2Ks phosphorylate MAPKs
_doRelease	TRUE
_timestamp	2019-08-08 17:17:26
authored	[InstanceEdit:5658468] Rothfels, Karen, 2014-12-18
catalystActivity	[CatalystActivity:5672974] protein serine/threonine kinase activity of activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5672975] Rothfels, Karen, 2015-02-06
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
input	[Complex:5672723] activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5673955] Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo [LiteratureReference:5673943] ERK1/2 MAP kinases: structure, function, and regulation [LiteratureReference:5673974] Total ERK1/2 activity regulates cell proliferation [LiteratureReference:5673941] Distinct functions for ERKs?
modified	[InstanceEdit:5674030] Rothfels, Karen, 2015-02-10 [InstanceEdit:5675238] Rothfels, Karen, 2015-02-15 [InstanceEdit:5678369] Rothfels, Karen, 2015-02-23 [InstanceEdit:5690599] Rothfels, Karen, 2015-04-29 [InstanceEdit:5691236] Rothfels, Karen, 2015-05-05 [InstanceEdit:5692890] Rothfels, Karen, 2015-05-13 [InstanceEdit:9657654] Rothfels, Karen, 2019-08-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MAP2Ks phosphorylate MAPKs
output	[Complex:5672724] activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:5672978] RAF phosphorylates MAP2K dimer [Homo sapiens] [Reaction:5672972] MAP2Ks and MAPKs bind to the activated RAF complex [Homo sapiens]
regulatedBy	[NegativeRegulation:9657615] Negative regulation by 'activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane]' [NegativeRegulation:9657612] Negative regulation by 'activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane]' [NegativeRegulation:9657617] Negative regulation by 'activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane]'
releaseDate	2015-06-17
releaseStatus	NEW
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695732] R-HSA-5672973.3
summation	[Summation:5674026] Activated MAP2K phosphorylates MAPK on threonine and tyrosin...
(hasEvent)	[Pathway:5674135] MAP2K and MAPK activation [Homo sapiens]
(normalReaction)	[Reaction:6802910] Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants [Homo sapiens] [Reaction:6802918] Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants [Homo sapiens] [Reaction:6802921] Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants [Homo sapiens] [Reaction:6802922] Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS [Homo sapiens] [Reaction:6802935] MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers [Homo sapiens] [Reaction:9656214] MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants [Homo sapiens]
(precedingEvent)	[Reaction:5672980] Dissociation of RAS:RAF complex [Homo sapiens] [Reaction:9657608] Single mechanism MAPK inhibitors bind phosphorylated MAPK [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777580] Update Tracker - [Reaction:5672973] MAP2Ks phosphorylate MAPKs - v70:[addRegulator] [_UpdateTracker:9782909] Update Tracker - [Reaction:5672973] MAP2Ks phosphorylate MAPKs - v58:[modifyText]
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No pathways have been reviewed or authored by MAP2Ks phosphorylate MAPKs (5672973)