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Details on Person MAP2Ks and MAPKs bind to the activated RAF complex

Class:Id	Reaction:5672972
_displayName	MAP2Ks and MAPKs bind to the activated RAF complex
_doRelease	TRUE
_timestamp	2015-05-25 03:48:39
authored	[InstanceEdit:5658468] Rothfels, Karen, 2014-12-18
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5672971] Rothfels, Karen, 2015-02-06
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
input	[Complex:5672718] p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] [Homo sapiens] [CandidateSet:5672717] RAF/MAPK scaffolds [cytosol] [Homo sapiens] [DefinedSet:5672716] MAP2K homo/heterodimers [cytosol] [Homo sapiens] [DefinedSet:169291] MAPKs [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5674433] Mek2 is dispensable for mouse growth and development [LiteratureReference:5674429] Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta [LiteratureReference:5673967] Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition [LiteratureReference:5673933] A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal [LiteratureReference:110038] A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function. [LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks [LiteratureReference:5673960] MEK1/2 dual-specificity protein kinases: structure and regulation [LiteratureReference:5673943] ERK1/2 MAP kinases: structure, function, and regulation [LiteratureReference:5673962] Protein scaffolds in MAP kinase signalling [LiteratureReference:5673947] IQGAP1 binds ERK2 and modulates its activity [LiteratureReference:5673950] IQGAP1 is a scaffold for mitogen-activated protein kinase signaling [LiteratureReference:5673951] IQGAP1 modulates activation of B-Raf [LiteratureReference:5673975] beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2 [LiteratureReference:5673972] The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation [LiteratureReference:5674381] Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis [LiteratureReference:208331] KSR and CNK: two scaffolds regulating RAS-mediated RAF activation [LiteratureReference:208164] Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression [LiteratureReference:208057] Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling [LiteratureReference:5673957] Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization [LiteratureReference:5674347] ERK dimers and scaffold proteins: unexpected partners for a forgotten (cytoplasmic) task
modified	[InstanceEdit:5674029] Rothfels, Karen, 2015-02-10 [InstanceEdit:5674390] Rothfels, Karen, 2015-02-11 [InstanceEdit:5674436] Rothfels, Karen, 2015-02-12 [InstanceEdit:5675236] Rothfels, Karen, 2015-02-15 [InstanceEdit:5678367] Rothfels, Karen, 2015-02-23 [InstanceEdit:5690601] Rothfels, Karen, 2015-04-29 [InstanceEdit:5691234] Rothfels, Karen, 2015-05-05 [InstanceEdit:5692888] Rothfels, Karen, 2015-05-13 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MAP2Ks and MAPKs bind to the activated RAF complex
output	[Complex:5672720] activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5672969] Phosphorylation of RAF [Homo sapiens] [Reaction:5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers [Homo sapiens]
regulatedBy	[NegativeRegulation:5675436] Negative regulation by 'p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane]'
releaseDate	2015-06-17
releaseStatus	NEW
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695731] R-HSA-5672972.3
summation	[Summation:5672603] RAF kinases have restricted substrate specificity and have a...
(hasEvent)	[Pathway:5674135] MAP2K and MAPK activation [Homo sapiens]
(normalReaction)	[Reaction:6802912] High kinase activity BRAF mutants bind MAP2Ks and MAPKs [Homo sapiens] [Reaction:6802914] RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs [Homo sapiens] [Reaction:6802925] Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs [Homo sapiens] [Reaction:6802934] p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs [Homo sapiens] [Reaction:6802942] RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs [Homo sapiens] [Reaction:9656211] MAP2Ks and MAPKs bind to the activated mutant RAF1 complex [Homo sapiens]
(precedingEvent)	[Reaction:5672978] RAF phosphorylates MAP2K dimer [Homo sapiens] [Reaction:9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks [Homo sapiens]
(replacementInstances)	[_Deleted:6798810] Deletion of instance: 109830
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No pathways have been reviewed or authored by MAP2Ks and MAPKs bind to the activated RAF complex (5672972)