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Details on Person RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers

Class:Id	Reaction:5672966
_displayName	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
_doRelease	TRUE
_timestamp	2015-05-25 03:48:38
authored	[InstanceEdit:5658468] Rothfels, Karen, 2014-12-18
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5672967] Rothfels, Karen, 2015-02-06
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
input	[Complex:5672729] p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] [Homo sapiens] [DefinedSet:5672731] dephosphorylated "receiver" RAF/KSR1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5672425] Active Ras induces heterodimerization of cRaf and BRaf [LiteratureReference:5672291] Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization [LiteratureReference:5672524] Regulation and role of Raf-1/B-Raf heterodimerization [LiteratureReference:444336] A dimerization-dependent mechanism drives RAF catalytic activation [LiteratureReference:5672158] Allosteric activation of functionally asymmetric RAF kinase dimers [LiteratureReference:5672468] MEK-1 activates C-Raf through a Ras-independent mechanism [LiteratureReference:5672144] "RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway [LiteratureReference:5675383] A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation [LiteratureReference:5675395] Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein [LiteratureReference:5675386] MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
modified	[InstanceEdit:5675260] Rothfels, Karen, 2015-02-15 [InstanceEdit:5675443] Rothfels, Karen, 2015-02-16 [InstanceEdit:5678397] Rothfels, Karen, 2015-02-23 [InstanceEdit:5690574] Rothfels, Karen, 2015-04-29 [InstanceEdit:5691264] Rothfels, Karen, 2015-05-05 [InstanceEdit:5692912] Rothfels, Karen, 2015-05-13 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
output	[Complex:5672733] p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5672950] "Activator" RAF:YWHAB dimer binds RAS:GTP [Homo sapiens] [Reaction:5672965] RAS GEFs promote RAS nucleotide exchange [Homo sapiens] [Reaction:9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 [Homo sapiens] [Reaction:5672958] YWHAB dimer dissociates from KSR1:MARK3 [Homo sapiens] [Reaction:5672957] PP2A dephosphorylates KSR1 [Homo sapiens]
regulatedBy	[NegativeRegulation:5674028] Negative regulation by 'BRAP:KSR1:MARK3 [cytosol]' [PositiveRegulation:5675439] Positive regulation by 'MAP3K11 [cytosol]'
releaseDate	2015-06-17
releaseStatus	NEW
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695729] R-HSA-5672966.3
summation	[Summation:5672621] RAF activation depends on the formation of a side-by-side as...
(hasEvent)	[Pathway:5673000] RAF activation [Homo sapiens]
(normalReaction)	[BlackBoxEvent:6803240] Homo- or heterodimerization of RAF downstream of mutant RAS [Homo sapiens] [Reaction:8936676] Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize [Homo sapiens] [Reaction:8936731] Inactive BRAF mutants:mutant RAS:GTP bind RAF1 [Homo sapiens] [Reaction:9656213] RAF1 mutants show enhanced heterodimerization with BRAF [Homo sapiens]
(precedingEvent)	[Reaction:5672969] Phosphorylation of RAF [Homo sapiens] [Reaction:9653108] Raf dimer inhibitors bind RAF heterodimers [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782898] Update Tracker - [Reaction:5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - v58:[modifyText] [_UpdateTracker:9783858] Update Tracker - [Reaction:5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - v55:[modifyText]
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