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Details on Person YWHAB dimer dissociates from dephosphorylated RAF

Class:Id	Reaction:5672960
_displayName	YWHAB dimer dissociates from dephosphorylated RAF
_doRelease	TRUE
_timestamp	2015-05-25 03:48:36
authored	[InstanceEdit:5658468] Rothfels, Karen, 2014-12-18
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5672959] Rothfels, Karen, 2015-02-06
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
input	[Complex:5672728] dephosphorylated inactive RAFS:YWHAB dimer [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:208298] Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites [LiteratureReference:208364] Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions [LiteratureReference:5672416] Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1 [LiteratureReference:5672264] Ras signaling: PP2A puts Ksr and Raf in the right place [LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks [LiteratureReference:5674056] Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration [LiteratureReference:5674049] Prohibitins role in cellular survival through Ras-Raf-MEK-ERK pathway [LiteratureReference:5674053] Ras-Raf signaling needs prohibitin
modified	[InstanceEdit:5674062] Rothfels, Karen, 2015-02-10 [InstanceEdit:5675255] Rothfels, Karen, 2015-02-15 [InstanceEdit:5678392] Rothfels, Karen, 2015-02-23 [InstanceEdit:5690623] Rothfels, Karen, 2015-04-29 [InstanceEdit:5691273] Rothfels, Karen, 2015-05-05 [InstanceEdit:5692917] Rothfels, Karen, 2015-05-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	YWHAB dimer dissociates from dephosphorylated RAF
output	[DefinedSet:5672726] dephosphorylated inactive RAFs [cytosol] [Homo sapiens] [Complex:2028645] YWHAB dimer [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5672961] PP2A dephosphorylates inactive RAFs [Homo sapiens] [Reaction:5672951] Inactive RAFs bind YWHAB [Homo sapiens]
releaseDate	2015-06-17
releaseStatus	NEW
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695726] R-HSA-5672960.2
summation	[Summation:5672609] Dephosphorylation of S259 (S365/S214) by PP2A promotes the t...
(hasEvent)	[Pathway:5673000] RAF activation [Homo sapiens]
(replacementInstances)	[_Deleted:6798801] Deletion of instance: 109803
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No pathways have been reviewed or authored by YWHAB dimer dissociates from dephosphorylated RAF (5672960)