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Details on Person AKT1S1 (PRAS40, proline-rich AKT/PKB substrate 40 kDa) is an...
| Class:Id | Summation:5672784 |
|---|---|
| _displayName | AKT1S1 (PRAS40, proline-rich AKT/PKB substrate 40 kDa) is an... |
| _timestamp | 2026-02-18 04:16:27 |
| created | [InstanceEdit:5672806] Jupe, Steve, 2015-02-06 |
| literatureReference | [LiteratureReference:377225] The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1 [LiteratureReference:377264] PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase [LiteratureReference:200166] Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40 [LiteratureReference:200154] Identification of a proline-rich Akt substrate as a 14-3-3 binding partner [LiteratureReference:377097] PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding [LiteratureReference:9647561] Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40 |
| modified | [InstanceEdit:5693184] Jupe, Steve, 2015-05-14 [InstanceEdit:9975208] Orlic-Milacic, Marija, 2025-11-28 [InstanceEdit:9975254] Orlic-Milacic, Marija, 2025-11-29 [InstanceEdit:9980736] Orlic-Milacic, Marija, 2026-02-02 [InstanceEdit:9982495] Orlic-Milacic, Marija, 2026-02-18 |
| text | AKT1S1 (PRAS40, proline-rich AKT/PKB substrate 40 kDa) is an mTORC1 accessory protein that binds the mTORC1 complex through direct interaction with its RAPTOR component (Wang et al. 2007: endogenous human protein in human embryonic kidney cell line HEK293) and with the mTOR kinase (Yang et al. 2018). The interaction with mTOR is induced under conditions that inhibit mTOR signalling, such as nutrient or serum deprivation or mitochondrial metabolic inhibition. AKT1S1 binding suppresses mTORC1-mediated phosphorylation of S6K1 and 4E-BP1 (Sancak et al. 2007, Vander Haar et al. 2008, Oshiro et al. 2007) by preventing binding of mTORC1 substrates to mTORC1 (Wang et al. 2007). AKT1S1 suppresses constitutive activation of mTORC1 in cells lacking TSC2. AKT1S1 silencing inactivates insulin-receptor substrate-1 (IRS-1) and AKT, and uncouples the response of mTOR to AKT signals. Furthermore, AKT1S1 phosphorylation by AKT and association with 14-3-3, a cytosolic anchor protein, are crucial for insulin to stimulate mTOR (Sancak et al. 2007, Vander Haar et al. 2008). PRAS40 is also a substrate of the mTORC1 complex (Kovacina et al. 2003, Oshiro et al. 2007). |
| (summation) | [Reaction:5672843] AKT1S1 (PRAS40) binds mTORC1 [Homo sapiens] |
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No pathways have been reviewed or authored by AKT1S1 (PRAS40, proline-rich AKT/PKB substrate 40 kDa) is an... (5672784)
