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Details on Person Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
| Class:Id | LiteratureReference:5672195 |
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| _displayName | Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF |
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| _timestamp | 2015-02-04 18:36:00 |
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| author | [Person:5672201] Heidorn, Sonja J
[Person:5672194] Milagre, Carla
[Person:5672197] Whittaker, Steven
[Person:5672193] Nourry, Arnaud
[Person:5672199] Niculescu-Duvas, Ion
[Person:5672196] Dhomen, Nathalie
[Person:5672198] Hussain, Jahan
[Person:2011697] Reis-Filho, JS
[Person:5672200] Springer, Caroline J
[Person:4613339] Pritchard, Catrin
[Person:1497943] Marais, R |
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| created | [InstanceEdit:5672192] Rothfels, Karen, 2015-02-04 |
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| journal | Cell |
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| pages | 209-21 |
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| pubMedIdentifier | 20141835 |
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| title | Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF |
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| volume | 140 |
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| year | 2010 |
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| (literatureReference) | [Complex:6802633] mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] [Homo sapiens]
[Complex:6802634] WT BRAF:inhibitors [cytosol] [Homo sapiens]
[Complex:6802674] mutant RAS:inactive BRAF:RAF1 [plasma membrane] [Homo sapiens]
[Pathway:5673000] RAF activation [Homo sapiens]
[Reaction:6802908] RAS mutants bind inactive RAF [Homo sapiens]
[Reaction:6802918] Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants [Homo sapiens]
[Reaction:6802924] RAF is phosphorylated downstream of oncogenic RAS [Homo sapiens]
[Reaction:6802937] Inactive BRAF mutants bind mutant RAS:GTP [Homo sapiens]
[Reaction:6802941] RAF is paradoxically phosphorylated downstream of kinase-inactive RAF [Homo sapiens]
[Reaction:6802942] RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs [Homo sapiens] |
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