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Details on Person Rheb in the MTORC1 complex hydrolyses GTP

Class:Id	Reaction:5672017
_displayName	Rheb in the MTORC1 complex hydrolyses GTP
_doRelease	TRUE
_timestamp	2020-04-15 12:45:59
authored	[InstanceEdit:5671581] Jupe, Steve, 2015-02-02
catalystActivity	[CatalystActivity:5672134] GTPase activity of MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane]
compartment	[Compartment:17938] lysosomal membrane
created	[InstanceEdit:5672023] Jupe, Steve, 2015-02-04
edited	[InstanceEdit:5692984] Jupe, Steve, 2015-05-13
goBiologicalProcess	[GO_BiologicalProcess:24370] regulation of macroautophagy
input	[Complex:5672812] MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:447068] AMPK phosphorylation of raptor mediates a metabolic checkpoint
modified	[InstanceEdit:5672124] Jupe, Steve, 2015-02-04 [InstanceEdit:5672806] Jupe, Steve, 2015-02-06 [InstanceEdit:5673006] Jupe, Steve, 2015-02-06 [InstanceEdit:5673013] Jupe, Steve, 2015-02-06 [InstanceEdit:5673770] Jupe, Steve, 2015-02-10 [InstanceEdit:5675792] Jupe, Steve, 2015-02-16 [InstanceEdit:5683339] Jupe, Steve, 2015-03-13 [InstanceEdit:5692976] Jupe, Steve, 2015-05-13 [InstanceEdit:5693009] Jupe, Steve, 2015-05-13 [InstanceEdit:5693824] Jupe, Steve, 2015-05-18 [InstanceEdit:6793655] Jupe, Steve, 2015-09-03 [InstanceEdit:8959542] D'Eustachio, Peter, 2017-01-26 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9638325] Varusai, Thawfeek, 2019-03-05 [InstanceEdit:9683409] Varusai, Thawfeek, 2020-04-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Rheb in the MTORC1 complex hydrolyses GTP
output	[Complex:5672139] MTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] [Homo sapiens]
precedingEvent	[Reaction:165680] Formation of active mTORC1 complex [Homo sapiens] [Reaction:165195] GTP loading by Rheb [Homo sapiens] [Reaction:5653968] Ragulator:Rag dimers:SLC38A9 bind mTORC1 [Homo sapiens] [Reaction:380927] p-AMPK phosphorylates TSC1:TSC2 [Homo sapiens] [Reaction:380930] Phosphorylated AMPK binds AMP [Homo sapiens] [Reaction:165179] Formation of TSC1:TSC2 complex [Homo sapiens]
regulatedBy	[PositiveRegulation:5672336] Positive regulation by 'TSC1:p-S1387-TSC2 [cytosol]'
releaseDate	2015-06-17
reviewed	[InstanceEdit:5693008] Tooze, Sharon A, 2015-05-13 [InstanceEdit:6793656] Klionsky, Daniel J, 2015-09-03
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9638297] Varusai, Thawfeek, 2019-03-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695715] R-HSA-5672017.7
summation	[Summation:5672128] When cellular energy is depleted AMPK is activated and inhib...
(hasEvent)	[Pathway:1632852] Macroautophagy [Homo sapiens]
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No pathways have been reviewed or authored by Rheb in the MTORC1 complex hydrolyses GTP (5672017)