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Details on Person The Beclin-1 complex (ATG14:PIK3C3:PIK3R4:BECN1) is essentia...

Class:IdSummation:5672016
_displayNameThe Beclin-1 complex (ATG14:PIK3C3:PIK3R4:BECN1) is essentia...
_timestamp2015-05-13 12:42:28
created[InstanceEdit:5672023] Jupe, Steve, 2015-02-04
literatureReference[LiteratureReference:5671582] Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
[LiteratureReference:5676013] Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L
[LiteratureReference:5666226] Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
[LiteratureReference:5676020] WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy
[LiteratureReference:5671594] WIPI proteins: essential PtdIns3P effectors at the nascent autophagosome
[LiteratureReference:5676007] Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation
[LiteratureReference:5679202] WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1
modified[InstanceEdit:5676019] Jupe, Steve, 2015-02-18
[InstanceEdit:5676240] Jupe, Steve, 2015-02-19
[InstanceEdit:5678281] Jupe, Steve, 2015-02-23
[InstanceEdit:5678304] Jupe, Steve, 2015-02-23
[InstanceEdit:5679261] Jupe, Steve, 2015-03-03
[InstanceEdit:5683339] Jupe, Steve, 2015-03-13
[InstanceEdit:5692976] Jupe, Steve, 2015-05-13
textThe Beclin-1 complex (ATG14:PIK3C3:PIK3R4:BECN1) is essential for autophagosome formation (Matsunaga et al. 2009, 2010). PIK3C3 (VPS34), the catalytic component of this complex, is a class III phosphatidylinositol 3-kinase that phosphorylates phosphatidylinositol (PI) producing phosphatidylinositol 3-phosphate (PI3P). PIK3C3 is essential for the early stages of autophagy and colocalizes strongly with early autophagosome markers (Axe et al. 2008). The role of PI3P in autophagosome formation is to recruit WIPI2b (Dooley et al. 2014) a member of the WIPI family (Proikas-Cezanne et al. 2004, 2015, Polson et al. 2010).
(summation)[Reaction:5672012] Beclin-1 complex phosphorylates PtdIns [Homo sapiens]
[Reaction:9015643] VBeclin-1 complex phosphorylates PtdIns [Homo sapiens]
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No pathways have been reviewed or authored by The Beclin-1 complex (ATG14:PIK3C3:PIK3R4:BECN1) is essentia... (5672016)
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