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Details on Person Active MTORC1 phosphorylates ULK1

Class:Id	Reaction:5672010
_displayName	Active MTORC1 phosphorylates ULK1
_doRelease	TRUE
_timestamp	2020-04-15 12:44:34
authored	[InstanceEdit:5671581] Jupe, Steve, 2015-02-02
catalystActivity	[CatalystActivity:5672132] protein serine/threonine kinase activity of MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane]
compartment	[Compartment:17938] lysosomal membrane
created	[InstanceEdit:5672023] Jupe, Steve, 2015-02-04
edited	[InstanceEdit:5692984] Jupe, Steve, 2015-05-13
goBiologicalProcess	[GO_BiologicalProcess:24370] regulation of macroautophagy
input	[Complex:5675639] MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5665936] The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR [LiteratureReference:5665841] AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
modified	[InstanceEdit:5672124] Jupe, Steve, 2015-02-04 [InstanceEdit:5672806] Jupe, Steve, 2015-02-06 [InstanceEdit:5673006] Jupe, Steve, 2015-02-06 [InstanceEdit:5673755] Jupe, Steve, 2015-02-10 [InstanceEdit:5675699] Jupe, Steve, 2015-02-16 [InstanceEdit:5692976] Jupe, Steve, 2015-05-13 [InstanceEdit:5693009] Jupe, Steve, 2015-05-13 [InstanceEdit:5693824] Jupe, Steve, 2015-05-18 [InstanceEdit:6793655] Jupe, Steve, 2015-09-03 [InstanceEdit:8959542] D'Eustachio, Peter, 2017-01-26 [InstanceEdit:9612935] Varusai, Thawfeek, 2018-07-05 [InstanceEdit:9613058] D'Eustachio, Peter, 2018-07-09 [InstanceEdit:9638325] Varusai, Thawfeek, 2019-03-05 [InstanceEdit:9681506] Varusai, Thawfeek, 2020-04-02 [InstanceEdit:9683409] Varusai, Thawfeek, 2020-04-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Active MTORC1 phosphorylates ULK1
output	[Complex:5675701] MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:5672817] Active MTORC1 binds the ULK1 complex [Homo sapiens] [Reaction:5672011] p-AMPK:AMP binds the ULK complex [Homo sapiens] [BlackBoxEvent:5683925] ULK1 is dephosphorylated [Homo sapiens]
releaseDate	2015-06-17
reviewed	[InstanceEdit:5693008] Tooze, Sharon A, 2015-05-13 [InstanceEdit:6793656] Klionsky, Daniel J, 2015-09-03
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9638297] Varusai, Thawfeek, 2019-03-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695712] R-HSA-5672010.7
summation	[Summation:5672020] Under nutrient-rich conditions, mTORC1 phosphorylates ULK1 o...
(hasEvent)	[Pathway:1632852] Macroautophagy [Homo sapiens]
(precedingEvent)	[Reaction:5673768] p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779139] Update Tracker - [Reaction:5672010] Active MTORC1 phosphorylates ULK1 - v66:[addInput, addOutput]
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No pathways have been reviewed or authored by Active MTORC1 phosphorylates ULK1 (5672010)