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Details on Person UniProt:P25092 GUCY2C
| Class:Id | ReferenceGeneProduct:56708 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Sat February 7 2015;chain:24-1073 added on Sat February 7 2015 |
| _displayName | UniProt:P25092 GUCY2C |
| _timestamp | 2024-11-03 20:01:11 |
| chain | signal peptide:1-23 chain:24-1073 |
| checksum | 486A4DE6F9097E22 |
| comment | FUNCTION Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP (PubMed:11950846, PubMed:1718270, PubMed:22436048, PubMed:22521417, PubMed:23269669). Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C (PubMed:1680854, PubMed:1718270). Also activated by the endogenous peptides guanylin and uroguanylin (PubMed:8381596).CATALYTIC ACTIVITY GTP = 3',5'-cyclic GMP + diphosphateSUBUNIT Homotrimer (PubMed:11123935). Interacts via its C-terminal region with NHERF4 (PubMed:11950846). Interacts with the lectin chaperone VIP36 (PubMed:23269669).INTERACTION The 145 kDa plasma membrane form of GUCY2C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form.DOMAIN The protein kinase domain is predicted to be catalytically inactive.PTM Glycosylation at Asn-75 and/or Asn-79 is required for interaction with VIP36 while glycosylation at Asn-345 and Asn-402 modulates ligand-mediated GUCY2C activation.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. |
| description | recommendedName: fullName evidence="15"Guanylyl cyclase C shortName evidence="15"GC-C ecNumber evidence="5 12 19"4.6.1.2 alternativeName: fullName evidence="16"Heat-stable enterotoxin receptor shortName evidence="16"STA receptor shortName evidence="16"hSTAR alternativeName: Intestinal guanylate cyclase |
| geneName | GUCY2C GUC2C STAR |
| identifier | P25092 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane cGMP biosynthesis Disease variant Endoplasmic reticulum Glycoprotein GTP-binding Lyase Membrane Nucleotide-binding Proteomics identification Receptor Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | GUCY2C |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991883] ENSEMBL:ENSG00000070019 GUCY2C [Homo sapiens] |
| secondaryIdentifier | GUC2C_HUMAN B2RMY6 |
| sequenceLength | 1073 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8936203] GUCY2C [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P25092 GUCY2C (56708)
