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Details on Person MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex

Class:Id	Reaction:5668978
_displayName	MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex
_doRelease	TRUE
_timestamp	2015-03-04 04:15:50
authored	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
catalystActivity	[CatalystActivity:445811] myosin light chain kinase activity of MYLK:Ca2+:CALM1 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5668981] Orlic-Milacic, Marija, 2015-01-29
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
inferredFrom	[Reaction:5672766] Turkey MYLK phosphorylates MRLCs of the non-muscle myosin II complex [Meleagris gallopavo]
input	[Complex:419194] Smooth muscle/non-muscle myosin II [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:425324] Identification, phosphorylation, and dephosphorylation of a second site for myosin light chain kinase on the 20,000-dalton light chain of smooth muscle myosin [LiteratureReference:5668847] Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase
modified	[InstanceEdit:5672755] Orlic-Milacic, Marija, 2015-02-06 [InstanceEdit:5672758] Orlic-Milacic, Marija, 2015-02-06 [InstanceEdit:5672770] Orlic-Milacic, Marija, 2015-02-06 [InstanceEdit:5673686] Orlic-Milacic, Marija, 2015-02-09 [InstanceEdit:5674244] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674554] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5674627] Orlic-Milacic, Marija, 2015-02-13 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex
output	[Complex:419195] p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:445797] MYLK (MLCK) Active Calmodulin Binding [Homo sapiens] [Reaction:74448] Calcium binds calmodulin [Homo sapiens]
regulatedBy	[NegativeRegulation:8981998] Negative regulation by 'Myosin phosphatase [cytosol]'
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680251] R-HSA-5668978.3
summation	[Summation:5672756] MYLK (MLCK) is a Ca2+/calmodulin-dependent myosin light chai...
(hasEvent)	[Pathway:5627123] RHO GTPases activate PAKs [Homo sapiens] [Pathway:9025112] (NEW)ROCK signaling regulates MRLC phosphorylation [Homo sapiens]
(precedingEvent)	[Reaction:419232] Myosin phosphatase dephosphorylates myosin regulatory light chain [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780934] Update Tracker - [Reaction:5668978] MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex - v61:[addRegulator]
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