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Details on Person PAK1 phosphorylates myosin phosphatase

Class:Id	Reaction:5668947
_displayName	PAK1 phosphorylates myosin phosphatase
_doRelease	TRUE
_timestamp	2017-03-15 15:32:35
authored	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
catalystActivity	[CatalystActivity:451358] protein serine/threonine kinase activity of p-S144,T423-PAK1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643844] protein serine/threonine kinase activity of p-S144,T423-PAK1 [cytosol] Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5668959] Orlic-Milacic, Marija, 2015-01-29
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
input	[Complex:419080] Myosin phosphatase [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5668951] Biphasic regulation of myosin light chain phosphorylation by p21-activated kinase modulates intestinal smooth muscle contractility
modified	[InstanceEdit:5668972] Orlic-Milacic, Marija, 2015-01-29 [InstanceEdit:5674244] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674554] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5676980] Orlic-Milacic, Marija, 2015-02-20 [InstanceEdit:8981921] Orlic-Milacic, Marija, 2017-03-15 [InstanceEdit:8981942] Orlic-Milacic, Marija, 2017-03-15 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PAK1 phosphorylates myosin phosphatase
output	[SimpleEntity:29370] ADP [cytosol] [Complex:5668948] p-T696-PPP1R12A-Myosin phosphatase [cytosol] [Homo sapiens]
precedingEvent	[Reaction:2029454] Autophosphorylation of PAK1 [Homo sapiens] [Reaction:5627775] Autophosphorylation of PAK1,2,3 [Homo sapiens] [Reaction:2029456] RAC1 and CDC42 activate PAK1 [Homo sapiens] [Reaction:8981931] RAC1 and CDC42 activate PAK2 [Homo sapiens] [Reaction:8981926] RAC1 and CDC42 activate PAK3 [Homo sapiens]
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679786] R-HSA-5668947.4
summation	[Summation:5668969] PAK1 phosphorylates the regulatory subunit MYPT1 (PPP1R12A) ...
(hasEvent)	[Pathway:5627123] RHO GTPases activate PAKs [Homo sapiens] [Pathway:9025112] (NEW)ROCK signaling regulates MRLC phosphorylation [Homo sapiens]
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No pathways have been reviewed or authored by PAK1 phosphorylates myosin phosphatase (5668947)