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Details on Person NOX3 complex:RAC1:GTP generates superoxide from oxygen

Class:Id	Reaction:5668731
_displayName	NOX3 complex:RAC1:GTP generates superoxide from oxygen
_doRelease	TRUE
_timestamp	2018-11-07 18:19:03
authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
catalystActivity	[CatalystActivity:5668737] superoxide-generating NAD(P)H oxidase activity of NOX3 complex:RAC1:GTP [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:5668739] Orlic-Milacic, Marija, 2015-01-26
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02 [InstanceEdit:9626901] Shamovsky, Veronica, 2018-10-29
input	[SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:352327] O2 [extracellular region] [SimpleEntity:352327] O2 [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:5668733] Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases [LiteratureReference:5668732] The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators [LiteratureReference:5668740] Role of the small GTPase Rac in p22phox-dependent NADPH oxidases [LiteratureReference:5668610] Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism
modified	[InstanceEdit:5668748] Orlic-Milacic, Marija, 2015-01-26 [InstanceEdit:5672372] Orlic-Milacic, Marija, 2015-02-05 [InstanceEdit:5674244] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674562] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9628189] Shamovsky, Veronica, 2018-11-07 [InstanceEdit:9628293] Shamovsky, Veronica, 2018-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOX3 complex:RAC1:GTP generates superoxide from oxygen
output	[SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:3299686] O2.- [extracellular region] [SimpleEntity:3299686] O2.- [extracellular region]
precedingEvent	[Reaction:5668735] RAC1:GTP binds NOX3 complex [Homo sapiens]
releaseDate	2015-03-19
reviewed	[InstanceEdit:9628191] N�sse, Oliver, 2018-11-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680296] R-HSA-5668731.3
summation	[Summation:5668745] While NOX3:CYBA complex has constitutive NADPH oxidase activ...
(hasEvent)	[Pathway:5668599] RHO GTPases Activate NADPH Oxidases [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778922] Update Tracker - [Reaction:5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen - v67:[add_removeInput, add_removeOutput]
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