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Details on Person cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK

Class:Id	BlackBoxEvent:5668534
_displayName	cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK
_doRelease	TRUE
_timestamp	2015-05-25 03:50:54
authored	[InstanceEdit:5668484] Garapati, Phani Vijay, 2015-01-26
catalystActivity	[CatalystActivity:5668529] ubiquitin-protein transferase activity of cIAP1,2:TRAF2:TRAF3:NIK [cytosol]
catalystActivityReference	[CatalystActivityReference:9643336] ubiquitin-protein transferase activity of cIAP1,2:TRAF2:TRAF3:NIK [cytosol] Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5668515] Garapati, Phani Vijay, 2015-01-26
edited	[InstanceEdit:5668484] Garapati, Phani Vijay, 2015-01-26
input	[Complex:5668435] cIAP1,2:TRAF2:TRAF3:NIK [cytosol] [Homo sapiens] [Polymer:912740] K48polyUb [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5668419] Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK [LiteratureReference:5668533] Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
modified	[InstanceEdit:5668904] Garapati, Phani Vijay, 2015-01-29 [InstanceEdit:5692512] Garapati, Phani Vijay, 2015-05-12 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK
output	[EntityWithAccessionedSequence:5668525] K48polyUb-NIK [cytosol] [Homo sapiens] [Complex:5668489] TRAF2:cIAP1,2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:914241] TRAF3 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5668543] TRAF3:NIK binds TRAF2:cIAP1/2 [Homo sapiens]
regulatedBy	[NegativeRegulation:5676484] Negative regulation by 'TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane]'
releaseDate	2015-06-17
releaseStatus	NEW
reviewed	[InstanceEdit:5692509] Ware, Carl F, Virgen-Slane, Richard, Rajput, Akhil, 2015-05-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695854] R-HSA-5668534.4
summation	[Summation:5668528] TNF receptor-associated factor 2 (TRAF2) and cellular inhibi...
(hasEvent)	[Pathway:5668541] TNFR2 non-canonical NF-kB pathway [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:5668520] 26Sproteasome degrades K48polyUb-NIK [Homo sapiens]
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