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Query author contributions in Reactome

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Details on Person TNF receptor-associated factor 2 (TRAF2) and cellular inhibi...

Class:IdSummation:5668528
_displayNameTNF receptor-associated factor 2 (TRAF2) and cellular inhibi...
_timestamp2015-01-29 12:12:11
created[InstanceEdit:5668515] Garapati, Phani Vijay, 2015-01-26
literatureReference[LiteratureReference:5657920] The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
[LiteratureReference:5668533] Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
modified[InstanceEdit:5668906] Garapati, Phani Vijay, 2015-01-29
textTNF receptor-associated factor 2 (TRAF2) and cellular inhibitors of apoptosis 1 and 2 (cIAP1,2) are both RING-containing ubiquitin protein ligase (E3), and the interplay between these two protein families and other molecules in the receptor complex is critical in the propagation of downstream signals (Rothe et al. 1995, Yang et al., 2000). cIAP1,2 initiates proteasomal degradation of NIK by mediating its K48-linked ubiquitination (K48-(Ub)n).
(summation)[BlackBoxEvent:5668534] cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK [Homo sapiens]
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