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Details on Person K48-linked ubiquitination of TRAF3 further leads to its prot...

Class:IdSummation:5668508
_displayNameK48-linked ubiquitination of TRAF3 further leads to its prot...
_timestamp2015-01-26 11:23:50
created[InstanceEdit:5668484] Garapati, Phani Vijay, 2015-01-26
literatureReference[LiteratureReference:5668488] The interaction between ER and NF?B in resistance to endocrine therapy
modified[InstanceEdit:5668515] Garapati, Phani Vijay, 2015-01-26
textK48-linked ubiquitination of TRAF3 further leads to its proteasome-dependent degradation. The resultant degradation of TRAF3 releases NIK from the cIAPs ubiquitin-ligase complex. NIK can escape from ubiquitination and subsequent degradation resulting in accumulation in the cytosol (Sas et al. 2012).
(summation)[BlackBoxEvent:5668481] Protesomal degradation of K48polyUb-TRAF3 [Homo sapiens]
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