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Details on Person Following recruitment to receptor, TRAF2 mediates K63-linked...

Class:IdSummation:5668492
_displayNameFollowing recruitment to receptor, TRAF2 mediates K63-linked...
_timestamp2015-02-19 18:30:31
created[InstanceEdit:5668484] Garapati, Phani Vijay, 2015-01-26
literatureReference[LiteratureReference:5668407] Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex
[LiteratureReference:5668503] Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling
[LiteratureReference:5668504] Self-termination of the terminator
modified[InstanceEdit:5668515] Garapati, Phani Vijay, 2015-01-26
[InstanceEdit:5676250] Garapati, Phani Vijay, 2015-02-19
textFollowing recruitment to receptor, TRAF2 mediates K63-linked polyubiquitination of cIAP1 and cIAP2. In addition to being an adaptor that recruits cIAP1/2 and TRAF3 to the receptor TRAF2 is also an E3 that activates cIAP1/2, through their K63-linked ubiquitination. This K63-linked ubiquitination stimulates the K48-ubiquitin ligase function of cIAP1/2 and may impose a change in the substrate specificity of cIAP1/2. Thus, rather than ubiquitinating NIK, cIAP1/2 ubiquitinates TRAF3 leading to its degradation (Vallabhapurapu et al. 2008, Wallach & Kovalenko 2008).
(summation)[BlackBoxEvent:5668414] TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK [Homo sapiens]
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