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Details on Person Protesomal degradation of K48polyUb-TRAF3

Class:Id	BlackBoxEvent:5668481
_displayName	Protesomal degradation of K48polyUb-TRAF3
_doRelease	TRUE
_timestamp	2015-05-25 03:50:52
authored	[InstanceEdit:5668484] Garapati, Phani Vijay, 2015-01-26
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5668484] Garapati, Phani Vijay, 2015-01-26
edited	[InstanceEdit:5668484] Garapati, Phani Vijay, 2015-01-26
input	[Complex:5668442] TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5668536] Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation [LiteratureReference:5668419] Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
modified	[InstanceEdit:5668515] Garapati, Phani Vijay, 2015-01-26 [InstanceEdit:5668904] Garapati, Phani Vijay, 2015-01-29 [InstanceEdit:5676588] Garapati, Phani Vijay, 2015-02-20 [InstanceEdit:5692512] Garapati, Phani Vijay, 2015-05-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Protesomal degradation of K48polyUb-TRAF3
output	[Complex:5668475] TRAF1:TRAF2:K63polyUb-cIAP1,2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:168189] MAP3K14 [cytosol] [Homo sapiens] [DefinedSet:5676550] TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:5668454] K63polyUb-cIAP1,2 ubiquitinates TRAF3 [Homo sapiens] [BlackBoxEvent:5668414] TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK [Homo sapiens]
releaseDate	2015-06-17
releaseStatus	NEW
reviewed	[InstanceEdit:5692509] Ware, Carl F, Virgen-Slane, Richard, Rajput, Akhil, 2015-05-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695852] R-HSA-5668481.2
summation	[Summation:5668508] K48-linked ubiquitination of TRAF3 further leads to its prot...
(hasEvent)	[Pathway:5668541] TNFR2 non-canonical NF-kB pathway [Homo sapiens]
(precedingEvent)	[Reaction:5607721] Activation of NIK [Homo sapiens] [Reaction:5668545] NIK autophosphorylates on T559 [Homo sapiens]
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