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Details on Person K63polyUb-cIAP1,2 ubiquitinates TRAF3

Class:Id	BlackBoxEvent:5668454
_displayName	K63polyUb-cIAP1,2 ubiquitinates TRAF3
_doRelease	TRUE
_timestamp	2015-05-25 03:50:51
authored	[InstanceEdit:5668484] Garapati, Phani Vijay, 2015-01-26
catalystActivity	[CatalystActivity:5668579] ubiquitin-protein transferase activity of TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5668484] Garapati, Phani Vijay, 2015-01-26
edited	[InstanceEdit:5668484] Garapati, Phani Vijay, 2015-01-26
input	[Complex:5668433] TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] [Homo sapiens] [Polymer:912740] K48polyUb [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5668407] Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex [LiteratureReference:5668419] Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK [LiteratureReference:5668503] Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling
modified	[InstanceEdit:5668515] Garapati, Phani Vijay, 2015-01-26 [InstanceEdit:5668580] Garapati, Phani Vijay, 2015-01-26 [InstanceEdit:5668904] Garapati, Phani Vijay, 2015-01-29 [InstanceEdit:5692512] Garapati, Phani Vijay, 2015-05-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	K63polyUb-cIAP1,2 ubiquitinates TRAF3
output	[Complex:5668442] TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:5668414] TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK [Homo sapiens] [Reaction:5668417] cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer [Homo sapiens]
releaseDate	2015-06-17
releaseStatus	NEW
reviewed	[InstanceEdit:5692509] Ware, Carl F, Virgen-Slane, Richard, Rajput, Akhil, 2015-05-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695851] R-HSA-5668454.2
summation	[Summation:5668432] cIAP1,2 targets NIK for ubiquitination and degradation under...
(hasEvent)	[Pathway:5668541] TNFR2 non-canonical NF-kB pathway [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:5668481] Protesomal degradation of K48polyUb-TRAF3 [Homo sapiens]
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